Splenic Marginal Zone Lymphoma C0349632
A slow-growing blood cancer that starts in the spleen affecting certain white blood cells. Usually occurs in older adults. Often managed with observation or spleen removal.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(oncologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Splenomegaly
(hematologic)Fatigue
(hematologic)Cytopenia
(hematologic)Night sweats
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Active surveillance
Regular monitoring without immediate intervention for early-stage or asymptomatic disease. Includes periodic imaging, blood work, and clinical evaluation to detect progression before initiating treatment.
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Splenectomy
Surgical removal of the spleen remains a cornerstone treatment for symptomatic splenomegaly or cytopenias in splenic marginal zone lymphoma. Can result in prolonged remission and hematologic improvement.
Additional treatment options
Rituximab-based therapy
Anti-CD20 monoclonal antibody used alone or in combination with chemotherapy agents. Provides effective disease control with manageable side effect profile, making it suitable for various patient populations.
medicationBendamustine plus rituximab
Combination immunochemotherapy regimen combining bendamustine with rituximab for patients requiring systemic treatment. This regimen has demonstrated efficacy in marginal zone lymphoma with manageable toxicity.
medicationInfection prophylaxis
Preventive antimicrobial therapy and vaccination strategy for patients with splenectomy or those receiving immunosuppressive treatment. Includes coverage for encapsulated bacteria and specific vaccines.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Splenic Marginal Zone Lymphoma C0349632?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Zucca E, Arcaini L, Buske C, et al. Marginal zone lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2020.
Kalpadakis C, Pangalis GA, Sachanas S, et al. Splenic marginal zone lymphoma: current knowledge and future directions. Leuk Lymphoma. 2018.
Iannitto E, Tripodo C, Ferreri AJ, et al. Rituximab plus bendamustine in untreated indolent B-cell lymphomas: a phase II study for splenic marginal zone lymphoma. Blood. 2016.
Piras IS, Bruscaggin A, Spina V, et al. Molecular pathogenesis of splenic marginal zone lymphoma. Haematologica. 2021.
Medication Comparisons
Compare medications used to treat Splenic Marginal Zone Lymphoma C0349632. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy