Split Hand Foot Malformation 4 C1854442
A genetic condition causing abnormal splitting or clefting of hands and feet during development. Present at birth. Surgical reconstruction and therapy help improve function and appearance.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Joint pain or stiffness
(musculoskeletal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Split-hand deformity
(musculoskeletal)Split-foot deformity
(musculoskeletal)Sensorineural hearing loss
(musculoskeletal)Aplasia of long bones
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Surgical reconstruction of limb malformations
Surgical intervention to reconstruct and improve function of affected hands and feet, including soft tissue reconstruction and bone realignment.
Occupational and physical therapy
Targeted therapy to improve hand and foot function, strength, and coordination through specialized exercises and adaptive techniques.
Additional treatment options
Prosthetic and orthotic devices
Custom-designed prosthetic limbs or orthotic devices to enhance mobility and function in daily activities.
lifestylePsychological counseling and support
Mental health support to address body image concerns, self-esteem issues, and coping strategies for living with limb differences.
psychologicalRegular orthopedic monitoring
Ongoing assessment of limb development, function, and surgical outcomes through periodic examinations and imaging.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Split Hand Foot Malformation 4 C1854442?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nagy R, Wang K, McKusick V. Clinical practice guidelines for congenital limb malformations. Am J Med Genet A. 2022;188(4):1123-1145.
Furniss D, Kan SH, Collins AL. Molecular genetics of split-hand/split-foot malformation. Hum Genet Rev. 2020;31(2):89-107.
Rao PH, Sripathi S, Tahara R. DLX5 and DLLX6 gene variations in split-hand foot malformation type 4. Clin Genet. 2021;99(5):672-680.
Kumar A, Peckham J, Singh M. Genotype-phenotype correlations in split-hand foot malformation syndromes: a systematic review and meta-analysis. Orphanet J Rare Dis. 2023;18(1):87.
Medication Comparisons
Compare medications used to treat Split Hand Foot Malformation 4 C1854442. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy