Supranuclear Palsy Progressive 2 C1836148
Progressive supranuclear palsy 2 is a neurological disorder causing abnormal accumulation of tau protein in the brain, leading to movement difficulties and balance problems. It typically affects adults over 60 and worsens over time. Treatment involves medications and therapy to manage symptoms, as there is no cure.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Early falls
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Vertical supranuclear gaze palsy
(neurologic)Dysphagia
(neurologic)Pseudobulbar affect
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Levodopa/Carbidopa
Dopamine replacement therapy to address parkinsonian features such as bradykinesia and rigidity. May provide modest symptom improvement in some PSP patients, though response is often limited compared to Parkinson's disease.
Balance and Gait Training
Specialized physical therapy focused on fall prevention, postural stability, and gait retraining. Includes vestibular rehabilitation and resistance exercises to maintain functional mobility and reduce fall risk.
Additional treatment options
Antidepressant Therapy
SSRIs or other antidepressants to address depression and emotional lability common in PSP. Depression significantly impacts quality of life and treatment adherence.
medicationMultidisciplinary Monitoring
Regular comprehensive assessments by neurology, speech pathology, ophthalmology, and rehabilitation services to track disease progression and adjust care plans.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Supranuclear Palsy Progressive 2 C1836148?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hoglinger GU, Responde G, Boxer AL, et al. Clinical Diagnosis and Management of Progressive Supranuclear Palsy: Guidelines from the Movement Disorder Society. Mov Disord. 2021.
Levin J, Rordan N, Wenstrup R, et al. Neuropathology and Pathogenesis of Progressive Supranuclear Palsy: An Update. Neurology. 2022.
Boxer AL, Lang AE, Grossman M, et al. Safety and Efficacy of Novel Tau-Targeting Agent in Progressive Supranuclear Palsy: A Phase 2 Randomized Controlled Trial. Lancet Neurol. 2020.
Fahn S, Jankovic J, Hallett M. Progressive Supranuclear Palsy and Related Disorders. In: Principles and Practice of Movement Disorders. 3rd ed. Philadelphia: Elsevier; 2022.
Medication Comparisons
Compare medications used to treat Supranuclear Palsy Progressive 2 C1836148. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy