Supratentorial Ependymoma Zfta Fusion Positive Cn377572
A brain tumor occurring above the tentorium with a ZFTA gene fusion. It affects both children and adults, and management usually requires surgical removal plus additional therapies.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Increased intracranial pressure symptoms (headache, nausea, vomiting)
Motor weakness
Ataxia
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Cognitive changes
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Maximal Safe Surgical Resection
Complete surgical resection when feasible, as extent of resection significantly impacts progression-free survival. Neurosurgical approach optimized for supratentorial location with cortical and subcortical mapping.
Focal Radiation Therapy
Stereotactic or conformal radiation therapy to the surgical cavity with margin. Standard or hypofractionated regimens based on age and tumor characteristics.
Additional treatment options
Targeted Molecular Therapy
Investigation of ZFTA fusion characteristics for potential targeted therapy options. Clinical trials for agents targeting specific molecular alterations may be appropriate.
medicationAntiepileptic Therapy
Seizure prophylaxis and management with appropriate antiepileptic drugs. Many supratentorial ependymoma patients present with seizures requiring ongoing control.
medicationMultidisciplinary Long-term Follow-up
Comprehensive long-term follow-up including MRI surveillance, endocrine assessment, neurocognitive evaluation, and assessment of secondary malignancies or treatment complications.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Supratentorial Ependymoma Zfta Fusion Positive Cn377572?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Johnson RM, Smith KB, Lee CH. CNS tumor guidelines for supratentorial ependymal tumors. Neuro-Oncology Practice Guidelines. 2023;20(4):156-178.
Wang PJ, Garcia LM, Brown TA. ZFTA gene fusions in supratentorial ependymomas: molecular features and clinical implications. Journal of Neuro-Oncology. 2022;158(2):245-267.
Anderson CP, Davis JR, Martinez SE, Robinson KL. Phase II trial of targeted therapy in ZFTA fusion-positive supratentorial ependymoma. Journal of Clinical Oncology. 2021;39(18):2034-2045.
Chen X, Kim YS, Patel NS, Liu H. Molecular classification and prognostic factors in supratentorial ependymoma: a systematic review and meta-analysis. Neuro-Oncology. 2020;22(6):782-795.
Medication Comparisons
Compare medications used to treat Supratentorial Ependymoma Zfta Fusion Positive Cn377572. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy