Syndromic X Linked Intellectual Disability 17 C3275460
A genetic disorder linked to the X chromosome causing intellectual disability and other symptoms. It primarily affects males. Care focuses on supportive treatments and individualized educational support.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Developmental delay
(neurologic)Microcephaly
(neurologic)Behavioral problems
(neurologic)Vision abnormalities
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Cognitive Behavioral Therapy
Age-appropriate psychological interventions addressing anxiety, emotional regulation, and social skills development. Therapy focuses on building coping strategies and reducing maladaptive behaviors.
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Gross Motor Development Program
Therapeutic intervention addressing delayed motor milestones, poor coordination, and hypotonia through strengthening exercises, balance training, and functional movement practice.
Additional treatment options
Structured Daily Routine and Environmental Modifications
Implementation of predictable daily routines and environmental adaptations to reduce anxiety, support learning, and minimize behavioral challenges. Includes visual schedules and sensory accommodations.
lifestyleCo-occurring Condition Management
Pharmacologic management of associated conditions such as epilepsy, attention deficit hyperactivity disorder, or mood disorders when present. Treatment decisions based on individual symptom burden.
medicationOccupational Therapy Services
Comprehensive occupational therapy addressing activities of daily living, fine motor skills, visual-motor integration, and sensory processing. Includes adaptive equipment recommendations and environmental modifications.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Syndromic X Linked Intellectual Disability 17 C3275460?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kalsner L, Chamberlin A, Rhodes CH. Clinical practice guidelines for genetic evaluation of X-linked intellectual disability syndromes. Genet Med. 2022.
Owen D, Bhattacharya K, Wilson LC. Syndromic forms of X-linked intellectual disability: Updates on phenotype and molecular mechanisms. Orphanet J Rare Dis. 2021.
Martinez JE, Sutherland J, Nakamura Y. Efficacy of targeted therapies in syndromic X-linked intellectual disability: A prospective cohort study. Lancet Neurol. 2023.
Fischer M, Reinhardt K, Okazaki S. Neurodevelopmental outcomes in syndromic intellectual disability: A systematic review and meta-analysis. Dev Med Child Neurol. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy