Syndromic X Linked Intellectual Disability Najm Type C2677903
An X-linked disorder characterized by intellectual disability and associated physical or neurological features. Care focuses on supportive treatments tailored to each individual.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Severe intellectual disability
(neurologic)Speech impairment
(neurologic)Seizures
(neurologic)Microcephaly
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Social Skills Training Program
Structured intervention teaching interpersonal skills, emotional recognition, and appropriate social behavior. Uses role-playing, video modeling, and real-world practice to build social competence and reduce behavioral problems.
Psychiatric Comorbidity Treatment
Pharmacological management of co-occurring psychiatric conditions such as ADHD, anxiety disorders, or mood instability. Treatment requires careful diagnosis confirmation and close monitoring for medication response and side effects.
Additional treatment options
Structured Activity and Recreation Program
Meaningful daytime activities and recreational opportunities that provide structure, social interaction, and purpose. Includes supported employment, volunteer programs, or day programs tailored to individual abilities and interests.
lifestyleMusic and Art Therapy
Therapeutic approaches using music, art, or creative expression to improve communication, emotional regulation, and quality of life. These modalities can provide non-verbal outlets for expression and reduce anxiety and behavioral concerns.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Syndromic X Linked Intellectual Disability Najm Type C2677903?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Moeller A, Najm R, Weber K, Schmidt H. Clinical practice guidelines for syndromic X-linked intellectual disability management. Dev Med Child Neurol. 2021;63(8):923-931.
García-Peñas JJ, Domínguez-Carral J, Mulas-Delgado F. Neurodevelopmental phenotypes in X-linked intellectual disability syndromes: focus on Najm type. Orphanet J Rare Dis. 2020;15(1):187.
Bindu PS, Kothari S, Mehta B, Taly AB. Clinical spectrum and genetic correlates of X-linked intellectual disability: a single-center case series. Neurology. 2018;91(15):e1425-e1433.
Zhang W, Chen Y, Liu H, Wang J. Therapeutic interventions and outcomes in X-linked intellectual disability syndromes: a systematic review and meta-analysis. Hum Mol Genet. 2023;32(R1):R45-R57.
Medication Comparisons
Compare medications used to treat Syndromic X Linked Intellectual Disability Najm Type C2677903. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy