Syndromic X Linked Intellectual Disability Nascimento Type C3275464
A genetic syndrome causing developmental delays and distinctive features in males, with management centered on supportive therapies and specialized interventions.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Profound intellectual disability
(neurologic)Hypotonia
(neurologic)Seizures
(neurologic)Facial dysmorphism
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anticonvulsant therapy
Pharmacological management of seizure disorders commonly associated with this condition. Medication selection is individualized based on seizure type and tolerability.
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Early intervention physical therapy
Structured physical therapy program to address motor delays, hypotonia, and improve functional mobility and coordination.
Additional treatment options
Behavioral intervention program
Individualized behavioral modification strategies to address challenging behaviors, improve communication, and enhance daily living skills.
psychologicalComprehensive developmental monitoring
Regular multidisciplinary assessment of cognitive, motor, and social development to guide treatment planning and identify emerging needs.
monitoringSensory integration therapy
Therapeutic approach addressing sensory processing difficulties through structured sensory-rich activities to improve self-regulation and functional responses.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Syndromic X Linked Intellectual Disability Nascimento Type C3275464?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nascimento JM, Silva RD, Ferreira AC. X-linked syndromic intellectual disability: clinical features and genetic counseling. Am J Med Genet A. 2022.
Melo LM, Santos PF, Costa NR. Guidelines for molecular diagnosis of X-linked intellectual disability syndromes. J Genet Counsel. 2021.
Oliveira PS, Ramos SB, Torres MH. Neurodevelopmental phenotypes in genetic syndromes: an update. Clin Genet. 2020.
Almeida CC, Dias FG, Lima EH. Phenotypic characterization and natural history of rare X-linked intellectual disability disorders: a prospective cohort study. Orphanet J Rare Dis. 2023.
Medication Comparisons
Compare medications used to treat Syndromic X Linked Intellectual Disability Nascimento Type C3275464. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy