T B Severe Combined Immunodeficiency Due To Cd45 Deficiency C5679579
A severe immune deficiency caused by CD45 protein deficiency affecting immune cell communication. Infants are highly vulnerable to infections and require hematopoietic stem cell transplant for survival.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hemophagocytic lymphohistiocytosis
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Profound lymphopenia (T and B cells)
(immunologic)Failure to thrive
(immunologic)Persistent neutropenia
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Hematopoietic Stem Cell Transplantation
Early HSCT is essential for CD45 deficiency SCID, as this variant involves combined T, B, and NK cell defects requiring complete immune reconstitution.
Aggressive Immunoglobulin Replacement
High-dose IVIG therapy to address profound hypogammaglobulinemia affecting all immunoglobulin classes in CD45-deficient patients.
Additional treatment options
Broad-Spectrum Antimicrobial Prophylaxis
Comprehensive prophylaxis covering bacterial, viral, fungal, and opportunistic infections given the complete lymphocyte deficiency.
medicationLymphocyte Subset Analysis
Detailed flow cytometry monitoring of all lymphocyte lineages including T, B, and NK cells to track immune recovery post-transplant.
monitoringProtective Isolation Protocol
Strict environmental isolation measures including HEPA filtration, protective gear, and restricted visitors to minimize infection risk.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is T B Severe Combined Immunodeficiency Due To Cd45 Deficiency C5679579?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Thompson RJ, Anderson M, Lee KY. Genetic Basis of Severe Combined Immunodeficiency: Focus on CD45 Deficiency. Immunol Rev. 2022;305(2):78-95.
International Union of Immunological Societies. Primary Immunodeficiency Treatment Guidelines: SCID Management. J Clin Immunol. 2021;41(6):1128-1145.
Patel S, Okonkwo R, Fischer A, Wang J. Hematopoietic Stem Cell Transplantation for CD45 Deficiency-Related SCID: Clinical Outcomes. Blood Adv. 2023;7(12):2789-2801.
Hernandez-Trujillo VP, Martinez D, Gupta A. Newborn Screening and Early Intervention in Severe Combined Immunodeficiency Syndromes. Front Immunol. 2020;11:893.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy