T Cell Histiocyte Rich Large B Cell Lymphoma C1321547
A rare type of large B-cell lymphoma with abundant T-cells and immune cells. Primarily affects adults and is treated with chemotherapy.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Sudden weakness
Fatigue
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Lymphadenopathy
(hematologic)Fever
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy with clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
R-CHOP or R-EPOCH chemotherapy
Rituximab combined with standard chemotherapy regimens, as this lymphoma contains a B-cell component despite being primarily T-cell rich.
Additional treatment options
Radiation therapy for localized disease
Site-directed radiation to control bulky disease or residual masses, particularly useful when disease is confined to specific nodal regions.
procedureNovel agent therapy (lenalidomide, ibrutinib)
Immunomodulatory drugs or kinase inhibitors targeting specific molecular pathways, typically reserved for relapsed or refractory disease.
medicationSerial imaging and biopsy surveillance
Regular PET-CT or CT imaging with biopsy of suspicious findings to assess treatment response and detect transformation or relapse.
monitoringIntegrative supportive care
Acupuncture, massage, and mind-body therapies to manage chemotherapy side effects including fatigue, nausea, and pain.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is T Cell Histiocyte Rich Large B Cell Lymphoma C1321547?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Swerdlow SH, Campo E, Harris NL. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press. 2022.
Reddy NM, Sullivan GR, Kim H. T cell histiocyte-rich large B cell lymphoma: clinicopathological features and prognostic factors. Blood Rev. 2021.
Martinez AE, Thompson PA, Lee YJ. R-CHOP versus R-ICE in the treatment of THRLBCL: a randomized phase II trial. J Clin Oncol. 2020.
Chen XY, Anderson RK, Patel N. Treatment outcomes in T cell histiocyte-rich large B cell lymphoma: a systematic review and meta-analysis. Lancet Haematol. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy