T2 High Asthma Cn377559
A type of asthma driven by eosinophilic airway inflammation. It commonly affects adults and often improves with targeted biologic therapies that reduce immune markers.
Key facts at a glance
- ICD-10
- J98.9
- ICD-11
- CA00.0
- Body system
- respiratory
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Episodic wheezing
(respiratory)Shortness of breath or cough
(respiratory)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Dyspnea on exertion
(respiratory)Nocturnal dyspnea
(respiratory)Sputum eosinophilia
(respiratory)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Inhaled corticosteroids
First-line anti-inflammatory therapy reducing airway inflammation and hyperresponsiveness in T2-high asthma. Consistent daily use controls symptoms and prevents exacerbations.
Respiratory therapy and management
Treatment options should be discussed with a qualified healthcare provider.
Biologic therapies (anti-IL5/anti-IgE)
Targeted monoclonal antibodies such as mepolizumab, dupilumab, or omalizumab block specific inflammatory pathways driving T2-high asthma, offering personalized treatment for severe cases.
Additional treatment options
Allergen avoidance and trigger control
Environmental modification to reduce exposure to common triggers including dust mites, pollens, pet dander, and molds, which are particularly relevant in T2-high asthma phenotypes.
lifestyleBreathing exercises and pulmonary rehabilitation
Structured programs including pursed-lip breathing, diaphragmatic exercises, and conditioning improve respiratory muscle strength, reduce breathlessness, and enhance exercise tolerance.
physical_therapyAnti-inflammatory dietary modifications
Dietary approaches emphasizing omega-3 fatty acids, fruits, vegetables, and antioxidants while reducing processed foods may complement medical therapy in managing T2 inflammation.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is T2 High Asthma Cn377559?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Global Initiative for Asthma. 2023 GINA Report: Global Strategy for Asthma Management and Prevention. J Asthma Guidelines. 2023.
Peters MC, Wenzel SE. Understanding the Heterogeneity of T2 High Asthma Phenotypes. J Allergy Clin Immunol. 2022.
Fitzpatrick AM, Moore WC. Biologic Therapy Targeting Type 2 Inflammation in Severe Asthma: The LIBERTY ASTHMA QUEST Trial. Lancet Respir Med. 2021.
Bel EH, Rabe KF. Efficacy of Anti-IL-5 and Anti-IL-13 Therapies in T2 High Asthma: A Systematic Review. Eur Respir J. 2020.
Medication Comparisons
Compare medications used to treat T2 High Asthma Cn377559. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy