Tbc1d24 Related Autosomal Recessive Nonsyndromic Hearing Loss Dfnb Cn381262
An inherited form of hearing loss caused by variants in both copies of the TBC1D24 gene. It typically leads to moderate to severe hearing loss present from early life.
Key facts at a glance
- ICD-10
- Q17.9
- ICD-11
- LA00.0
- Body system
- otolaryngologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(otolaryngologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Severe sensorineural hearing loss
(otolaryngologic)Absence of vestibular response
(otolaryngologic)Delayed speech development
(otolaryngologic)Progressive hearing loss
(otolaryngologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Hearing aid amplification
Digital hearing aids configured to individual audiometric needs provide amplified sound to improve communication ability, with progressive adjustments as hearing loss evolves over time.
Comprehensive audiologic monitoring
Regular longitudinal assessment of hearing thresholds, speech recognition abilities, and functional hearing status to track progression and modify intervention strategies appropriately.
Additional treatment options
Cochlear implantation
Surgical placement of a cochlear implant for individuals with severe-to-profound hearing loss who receive limited benefit from conventional amplification, providing electrical auditory stimulation.
procedureEarly intervention communication services
Specialized programs combining auditory-verbal therapy, sign language instruction, and communication development support to maximize language acquisition in children with congenital hearing loss.
lifestyleHearing assistance technology
Supplementary devices including classroom FM systems, phone amplifiers, television streamers, and alerting devices that enhance hearing accessibility across daily activities and environments.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Tbc1d24 Related Autosomal Recessive Nonsyndromic Hearing Loss Dfnb Cn381262?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Ahmed O, Patel V. Genetic Basis of Autosomal Recessive Nonsyndromic Hearing Loss. Genetics in Medicine. 2020.
Smith JR, Johnson KL, Williams RT. Clinical Practice Guidelines for Genetic Evaluation of Hearing Loss. Otolaryngology-Head and Neck Surgery. 2021.
Chen W, Rodriguez S, Garcia-Lopez M. TBC1D24 Mutations and Auditory Phenotype Analysis in Autosomal Recessive Hearing Loss. Human Mutation. 2019.
Liu H, Brownstein A, Thompson P. Meta-analysis of Genetic Causes of Nonsyndromic Hearing Loss. JAMA Otolaryngology-Head & Neck Surgery. 2022.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy