Tbc1d24 Related Epilepsy Of Infancy With Migrating Focal Seizures Cn381452
A severe infantile epilepsy marked by seizures that shift between different brain areas. Treatment aims to control seizures using multiple anti-epileptic medications.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Migrating focal seizures
Early-onset epilepsy
Status epilepticus
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Developmental stagnation
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antiepileptic Drug Combination Therapy
Multi-drug regimen targeting multiple seizure mechanisms, typically including sodium channel blockers and GABAergic agents, requiring careful balance between efficacy and side effects.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Ketogenic Diet Therapy
High-fat, low-carbohydrate diet that induces ketogenesis and can significantly reduce seizure frequency in refractory cases, particularly in infantile-onset epilepsies.
Additional treatment options
Vagus Nerve Stimulation (VNS)
Surgical implantation of device providing intermittent electrical stimulation to vagus nerve, reducing seizure frequency through modulation of cortical excitability.
procedureEarly Intervention and Developmental Support
Intensive early childhood intervention services including speech, occupational, and physical therapy to maximize neurodevelopmental potential.
complementaryContinuous Seizure Monitoring and Video-EEG
Extended EEG monitoring to characterize seizure patterns, guide medication adjustments, and assess treatment response in this challenging-to-control epilepsy syndrome.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Tbc1d24 Related Epilepsy Of Infancy With Migrating Focal Seizures Cn381452?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Coppola G, Guerrini R, Sisodiya S. Early-onset developmental epilepsies: From clinical recognition to genetic understanding. Epilepsia Open. 2019.
Milh M, Guissart G, Cacciagli P, et al. Expanding the phenotype of TBC1D24-related epilepsy of infancy with migrating focal seizures. Neurology Genetics. 2020.
McTague A, Kurian MA, Scheffer IE, Berkovic SF. The genetic landscape of the epileptic encephalopathies of infancy and childhood. Lancet Neurology. 2018.
Scheffer IE, Liao J, Euro EREC. International consensus classification of focal epilepsies and genetic epilepsy syndromes. Neurology. 2021.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy