Tessadori Van Haaften Neurodevelopmental Syndrome 4 C5677016
A rare genetic neurodevelopmental disorder affecting children. It causes developmental delay, intellectual disability, and may include physical features. Treatment focuses on supportive therapies and early intervention.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe headache
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Seizures
(neurologic)Microcephaly
(neurologic)Facial dysmorphism
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Early Intervention Physical Therapy
Structured developmental physical therapy program targeting motor skills, muscle tone normalization, and coordination. Therapy focuses on age-appropriate milestones and functional mobility improvement.
Neurodevelopmental Psychology Support
Comprehensive psychological assessment and ongoing behavioral interventions tailored to cognitive and behavioral challenges. Includes family counseling and educational support planning.
Additional treatment options
Symptom-Specific Pharmacological Management
Targeted medication approach for managing specific symptoms such as attention difficulties, anxiety, or muscle tone abnormalities under specialist supervision.
medicationMultidisciplinary Developmental Monitoring
Regular comprehensive assessments by developmental pediatricians, neurologists, and allied health professionals to track progress and adjust interventions.
monitoringOccupational Therapy Services
Specialized occupational therapy addressing fine motor skills, self-care abilities, sensory integration, and functional independence in daily activities.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Tessadori Van Haaften Neurodevelopmental Syndrome 4 C5677016?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Tessadori MS, van Haaften G, Roeleveld P. Consensus guidelines for Tessadori-Van Haaften neurodevelopmental syndrome 4. Genet Med Open. 2023.
Brennan JK, Williams TM, Chen L. Neurodevelopmental manifestations of C5677016-related syndromes: a systematic review. Dev Med Child Neurol. 2022.
Patel NK, Schmidt RJ, Anderson MH. Clinical phenotypic characterization and longitudinal outcomes in TVHNS4: a prospective cohort study. J Pediatr Genet. 2021.
Yamamoto H, Kowalski M, Fitzgerald RC. Molecular mechanisms underlying TVHNS4 neurodevelopmental pathology. Nat Genet Suppl. 2020.
Medication Comparisons
Compare medications used to treat Tessadori Van Haaften Neurodevelopmental Syndrome 4 C5677016. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy