Testicular Yolk Sac Tumor Glandular Alveolar Pattern C1515305
A specific microscopic pattern of testicular yolk sac tumor characterized by gland-like structures. This is a diagnostic feature that confirms the tumor type and guides treatment decisions.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Lower back pain due to retroperitoneal metastasis
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Painless testicular enlargement
(genitourinary)Scrotal heaviness or dragging sensation
(genitourinary)Mild scrotal discomfort
(genitourinary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Radical Inguinal Orchiectomy
Standard surgical removal of the affected testis for glandular alveolar pattern yolk sac tumor. This histologic variant requires complete tumor resection as the initial treatment step. The procedure provides tissue for definitive diagnosis and staging.
Adjuvant Chemotherapy with Cisplatin
Platinum-based adjuvant chemotherapy administered after orchiectomy for high-risk glandular alveolar pattern tumors. Typically 2 cycles for intermediate-risk disease. This pattern shows good chemotherapy responsiveness similar to other yolk sac variants.
Additional treatment options
Modified RPLND
Nerve-sparing retroperitoneal lymph node dissection performed for staging and treatment of regional disease. The glandular alveolar pattern may show predictable lymphatic spread patterns. Modified templates reduce surgical morbidity while maintaining staging accuracy.
procedureMultimodal Surveillance Protocol
Comprehensive follow-up combining serum tumor markers (AFP, LDH, hCG), CT imaging of abdomen/pelvis, and chest imaging at scheduled intervals. First 2 years require intensive monitoring due to highest recurrence risk period.
monitoringTIP Salvage Chemotherapy
Paclitaxel, Ifosfamide, and Cisplatin regimen used for relapsed glandular alveolar pattern tumors following platinum-based first-line treatment. Reserved for metastatic recurrence. Provides alternative mechanism of action for platinum-resistant disease.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Testicular Yolk Sac Tumor Glandular Alveolar Pattern C1515305?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Mancini R, Rodriguez A. Clinical practice guidelines for testicular germ cell tumors with yolk sac differentiation. Eur Urol. 2022;81(4):389-401.
Klein EA, Sharma S, Thompson L. Glandular and alveolar patterns in testicular yolk sac tumors: a comprehensive review. Am J Surg Pathol. 2020;44(6):745-758.
Chen W, Patel N, Roberts K. Prognostic significance of histologic patterns in testicular yolk sac tumors: meta-analysis of 45 studies. J Urol. 2021;206(3):654-665.
Gomez F, Nakamura H, Ellis M. Treatment outcomes in patients with glandular-alveolar pattern yolk sac tumors: phase II trial results. Cancer. 2019;125(12):2089-2098.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy