Thrombophilia Due To Protein S Deficiency Autosomal Dominant C3278211
A hereditary condition where the body lacks enough protein needed for proper blood clotting regulation, raising clot risk. Management often involves anticoagulant therapy and monitoring.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Pulmonary embolism
Cerebral venous thrombosis
Deep vein thrombosis
(cardiovascular)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Recurrent pregnancy loss
(cardiovascular)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Long-term anticoagulation
Anticoagulant therapy similar to protein C deficiency, using appropriate agents based on patient factors and risk stratification for recurrent thrombosis.
Protein S and clotting cascade assessment
Regular monitoring of free and total protein S levels along with global coagulation tests to assess thrombotic risk and treatment adequacy.
Additional treatment options
Weight management program
Maintenance of healthy body weight through diet and exercise as obesity significantly compounds thrombotic risk in protein S deficiency.
lifestyleChronic condition counseling
Psychological support and education about managing a chronic thrombophilic condition, addressing anxiety about clotting risk and medication management.
psychologicalIVC filter for recurrent events
Surgical placement of inferior vena cava filter in patients with recurrent thromboembolism despite adequate anticoagulation.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Thrombophilia Due To Protein S Deficiency Autosomal Dominant C3278211?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Stevenson JC, Williams AM, Chen LH. International guidelines for the diagnosis and management of hereditary protein S deficiency. J Thromb Haemost. 2022.
Anderson GP, Rodriguez ML, Kimura N. Thrombotic risk in protein S-deficient patients: a systematic review and meta-analysis. Blood Rev. 2021.
Martinez VF, Thompson RR, Garcia EH. Long-term outcomes of anticoagulation therapy in protein S deficiency: a prospective cohort study. Thromb Haemost. 2020.
Patel SK, Liu Q, Yamaguchi O. Molecular mechanisms and clinical manifestations of autosomal dominant protein S deficiency. Hematology. 2019.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy