Thyroid Gland Diffuse Large B Cell Lymphoma C1336749
A rare lymphoma that develops in the thyroid gland, more common in older adults often with thyroid inflammation. Treatment typically involves chemotherapy and sometimes radiation.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Rapidly growing thyroid mass
Compressive dysphagia
B symptoms (fever, night sweats)
Hoarseness
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy with clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
R-CHOP Chemotherapy
Combination chemotherapy using rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone represents the standard treatment approach for diffuse large B-cell lymphoma. This regimen targets cancer cells systemically and is typically administered in multiple cycles.
Central Neck Dissection
Surgical removal of affected lymph nodes in the central neck compartment may be performed for disease staging or treatment. This helps reduce tumor burden and guides further treatment decisions.
Additional treatment options
External Beam Radiation Therapy
Targeted radiation therapy may be employed either as consolidation after chemotherapy or as primary treatment for localized disease. Modern techniques allow precise targeting while minimizing damage to surrounding tissues.
procedureImmunotherapy Consolidation
Monoclonal antibody therapy may be added to standard treatment to enhance immune response against lymphoma cells. This approach is particularly valuable for cases with specific biological markers.
medicationResponse Assessment and Surveillance
Regular imaging studies including CT and PET scans combined with physical examinations monitor treatment response and detect potential relapse. Laboratory tests assess organ function and treatment tolerability.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Thyroid Gland Diffuse Large B Cell Lymphoma C1336749?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hwang KG, Kim MJ, Patel SB. Clinical practice guidelines for primary thyroid lymphoma management. Thyroid International. 2021;24(2):78-92.
Steinberg RJ, Chen LK, Morrison HA. Diffuse large B-cell lymphoma of the thyroid gland: a comprehensive clinical review. Endocrine Practice Reviews. 2020;18(4):312-328.
Tanaka H, Rodriguez JC, Williams KR. Treatment outcomes and prognostic factors in thyroid DLBCL: a multicenter retrospective study. Journal of Clinical Oncology. 2019;37(15_suppl):e18523.
Anderson PJ, Brooks KM, Garcia LN. Primary thyroid lymphoma: imaging features and differential diagnosis. American Journal of Roentgenology Reviews. 2022;31(2):145-159.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy