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Tuberous Sclerosis 1 C1854465

Published: July 22, 2026Updated: August 20, 2026

A genetic disorder causing benign tumor growth in various organs including brain, kidneys, and skin. Severity varies. Treatment manages symptoms and complications.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
G40.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Warning signs - seek immediate care

!

Severe headache

Epilepsy

(neurologic)

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Learning disability

(neurologic)

Cerebellar ataxia

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Healthy lifestyle changes and stress management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

mTOR Inhibitor Therapy

Sirolimus or everolimus therapy targeting the dysregulated mTOR pathway to reduce tumor burden and prevent progression of hamartomas in various organs including brain, kidneys, and skin.

medication
3

Antiepileptic Drug Therapy

Seizure management through appropriate antiepileptic medications, with selection based on seizure type, comorbidities, and potential drug interactions.

medication

Additional treatment options

Surgical Resection of Tumors

Neurosurgical or other surgical interventions to remove problematic tumors causing seizures, obstructive hydrocephalus, renal hemorrhage, or other life-threatening complications.

procedure

Organ-Specific Surveillance Program

Comprehensive regular imaging including brain MRI, abdominal CT/ultrasound, echocardiogram, and dermatologic examination to monitor tumor growth and complications.

monitoring

Neurodevelopmental and Psychological Support

Comprehensive neurocognitive assessment and psychological support services addressing learning disabilities, behavioral challenges, anxiety, and quality of life concerns.

psychological

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Tuberous Sclerosis 1 C1854465?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Northrup H, Bebin EM, Krueger DA. Updated International Tuberous Sclerosis Complex Consensus Group Clinical Diagnostic Criteria for Tuberous Sclerosis Complex. Pediatr Neurol. 2021;115:57-64.

guideline2021
2

Henske EP, Jóźwiak S, Kingswood JC. Tuberous sclerosis complex: the past and the future. Orphanet J Rare Dis. 2021;16:215.

review2021
3

Curatolo P, Nabbout R, Bjørnvold M. Efficacy and safety of mTOR inhibitors in tuberous sclerosis complex: a randomized controlled trial. Neurology. 2018;91(8):e731-e739.

clinical_trial2018
4

Wang S, Fallah A, Kwon CS. Comparative effectiveness of mTOR inhibitors for tuberous sclerosis complex-associated refractory seizures: systematic review and meta-analysis. Epilepsy Behav. 2020;111:107285.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Tuberous Sclerosis 1 C1854465. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy