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Tuberous Sclerosis 2 C1860707

Published: July 22, 2026Updated: August 20, 2026

A genetic condition causing non-cancerous tumors in multiple organs. Often involves the brain, skin, and kidneys. Regular monitoring and symptom management are key.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
G40.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Warning signs - seek immediate care

!

Severe headache

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Infantile spasms

(neurologic)

Cortical dysplasia

(neurologic)

Subependymal giant cell astrocytoma

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Dietary counseling and physical activity plan

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

mTOR Inhibitor Therapy

Everolimus or sirolimus therapy for TSC2 to inhibit abnormal cell growth, reduce subependymal giant cell astrocytoma size, treat renal angiomyolipomas, and manage skin lesions.

medication
3

Everolimus for Refractory Seizures

Adjunctive everolimus specifically for treatment-resistant seizures in TSC2, which may reduce seizure frequency significantly in many patients.

medication

Additional treatment options

Surgical Intervention for SEGA

Neurosurgical procedures for subependymal giant cell astrocytomas causing obstructive hydrocephalus, significant mass effect, or refractory symptoms despite medical therapy.

procedure

Renal Intervention for Angiomyolipomas

Embolization, nephron-sparing surgery, or ablation techniques for bleeding or large angiomyolipomas, preserving kidney function while preventing complications.

procedure

TSC Center of Excellence Follow-up

Regular multidisciplinary follow-up at a TSC clinic or center of excellence coordinating neurology, nephrology, dermatology, genetics, and developmental services.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Tuberous Sclerosis 2 C1860707?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Northrup H, et al. Updated International Tuberous Sclerosis Complex Consensus Group Clinical Diagnostic Criteria for Tuberous Sclerosis Complex. Pediatric Neurology. 2021;124:1-10.

guideline2021
2

Franz DN, et al. Efficacy and safety of mTOR inhibitors in tuberous sclerosis complex: A randomized controlled trial. Lancet Neurology. 2019;18(11):1016-1025.

clinical_trial2019
3

Kingswood JC, et al. The association between renal angiomyolipomas and lymphangioleiomyomatosis in tuberous sclerosis complex: A meta-analysis. Kidney Int. 2016;90(4):784-790.

meta_analysis2016
4

Curatolo P, et al. Mechanistic target of rapamycin pathway in tuberous sclerosis complex: A comprehensive review. Lancet Neurology. 2020;19(8):654-669.

review2020

Medication Comparisons

Compare medications used to treat Tuberous Sclerosis 2 C1860707. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy