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Tuberous Sclerosis 4 Cn229774

Published: July 22, 2026Updated: August 27, 2026

A genetic condition related to tuberous sclerosis complex. Causes tumor growth in different body parts. Treatment focuses on managing tumors and preventing complications.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 27, 2026Editorial policy

Key facts at a glance

ICD-10
G40.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Warning signs - seek immediate care

!

Infantile spasms

!

Refractory epilepsy

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Intellectual disability

(neurologic)

Autism spectrum disorder

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Exercise prescription and weight management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

mTOR Inhibitor Therapy

Targeted mTOR inhibitor therapy addresses the dysregulated cellular growth pathways characteristic of this tuberous sclerosis variant, effectively shrinking skin lesions, renal tumors, and brain lesions.

medication
3

Dermatological Laser Treatment

Pulsed dye laser or CO2 laser therapy for facial angiofibromas and hypomelanotic macules to improve cosmetic appearance and reduce skin-related distress.

procedure

Additional treatment options

Anti-seizure Pharmacotherapy

Individualized anticonvulsant regimen tailored to seizure type, which may include multiple agents depending on electroencephalogram findings and clinical response.

medication

Cardiac Echocardiography

Regular cardiac ultrasound to monitor rhabdomyomas, which are common cardiac tumors in tuberous sclerosis that may cause arrhythmias or obstruction in young children.

monitoring

Behavioral Intervention Program

Structured behavioral therapy addressing autism spectrum symptoms, aggression, and anxiety through applied behavior analysis techniques tailored to neurodevelopmental needs.

psychological

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Tuberous Sclerosis 4 Cn229774?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Northrup H, Au KS, Bebin EM, et al. Tuberous Sclerosis Complex Diagnostic Criteria Update: Recommendations of the 2022 International Tuberous Sclerosis Complex Consensus Group. Pediatr Neurol. 2022;128:53-64.

guideline2022
2

Crino PB, Nathanson KL, Henske EP. The tuberous sclerosis complex. N Engl J Med. 2011;365(18):1721-1732.

review2011
3

Curatolo P, Moavero R, de Vries PJ. Everolimus for Subependymal Giant Cell Astrocytoma in Patients with Tuberous Sclerosis Complex: Long-Term Follow-Up of theEXIST-1 Trial. Neurology. 2015;85(19):1651-1658.

clinical_trial2015
4

Sweeney SM, Ewalt DR, Bates W, Roach ES. Mammalian target of rapamycin (mTOR) inhibitor therapy in tuberous sclerosis complex: a systematic review and meta-analysis. Orphanet J Rare Dis. 2019;14(1):89.

meta_analysis2019

Medication Comparisons

Compare medications used to treat Tuberous Sclerosis 4 Cn229774. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy