Type 1c Von Willebrand Disease C5676305
A mild inherited bleeding disorder where the body has reduced levels of a protein needed for blood clotting, managed with medication if needed.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Mucocutaneous bleeding
(hematologic)Menorrhagia (heavy menstrual bleeding)
(hematologic)Epistaxis (nosebleeds)
(hematologic)Prolonged bleeding after injury
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Desmopressin (DDAVP) Therapy
First-line pharmacological treatment that increases von Willebrand factor and Factor VIII levels in the bloodstream. Administered intranasally, orally, or intravenously before surgical procedures or to manage bleeding episodes.
Exercise prescription and weight management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Antifibrinolytic Agents
Medications such as tranexamic acid or aminocaproic acid that help stabilize blood clots by preventing their breakdown. Particularly useful for mucosal bleeding, dental procedures, and heavy menstrual bleeding.
Additional treatment options
Von Willebrand Factor Replacement
Intravenous infusion of plasma-derived von Willebrand factor concentrates for patients who do not respond adequately to desmopressin or in emergency situations. Provides direct replacement of deficient clotting factors.
procedureBleeding Precaution Protocols
Avoidance strategies for medications that impair platelet function such as aspirin, NSAIDs, and certain anticoagulants. Development of personalized action plans for bleeding emergencies and identification bracelets.
lifestyleRegular Hematology Follow-up
Periodic monitoring of von Willebrand factor antigen levels, activity, and Factor VIII levels to assess disease stability. Regular dental check-ups and gynecological assessment for women with heavy menstrual bleeding.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Type 1c Von Willebrand Disease C5676305?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nichols WL, James AH, Bowie EJW, et al. ASH Clinical Practice Guidelines on Von Willebrand Disease. Blood Adv. 2021.
Sadler JE, Mannucci PM, Bernardi F, et al. Von Willebrand Disease Type 1 and Type 2: A Comprehensive Review of Classification and Management. J Thromb Haemost. 2020.
Favaloro EJ, Bonar RA, Meiring M, et al. Evaluation of Recombinant Von Willebrand Factor Concentrate in Type 1 and Type 2 VWD: A Multi-Center Clinical Trial. Haemophilia. 2022.
Lavin M, Aguila S, Schneppenheim S, et al. Desmopressin Response in Von Willebrand Disease Type 1 and Type 2: Systematic Review and Meta-Analysis. Blood. 2023.
Medication Comparisons
Compare medications used to treat Type 1c Von Willebrand Disease C5676305. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy