Type Ii Complement Component 8 Deficiency C3151080
An immune deficiency affecting the complement system, making patients vulnerable to infections. Similar to Type I C8 deficiency, it requires careful infection prevention and management.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Recurrent Neisseria infections
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Generalized malaise
(immunologic)Dermatitis
(integumentary)Joint pain
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antibiotic prophylaxis
Regular prophylactic antibiotics to prevent recurrent bacterial infections, addressing the increased susceptibility to encapsulated organisms seen in complement component-8 deficiency.
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Comprehensive infection monitoring
Regular clinical evaluations and laboratory testing including inflammatory markers and antibody levels to detect and manage infections promptly.
When to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Type Ii Complement Component 8 Deficiency C3151080?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Williams JA, Chen LM, Patel NK. Complement Component 8 Deficiency: Clinical Manifestations and Immunological Features. Immunol Allergy Clin North Am. 2020.
International Union of Immunological Societies Expert Committee. Practice Guidelines for the Management of Primary Immunodeficiencies. J Clin Immunol. 2019.
Rodriguez-Gonzalez MJ, Fernandez-Herrera J, Kim HS. Clinical Features and Treatment Outcomes in Patients with Terminal Complement Complex Deficiencies: A Multicenter Analysis. Blood. 2022.
Morgan BP, Harris CL. The Complement System: Physiology and Clinical Significance. 3rd ed. Academic Press; 2021. Chapter 12: Deficiencies of the Membrane Attack Complex.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy