Vaginal Yolk Sac Tumor C1336945
A rare malignant germ cell tumor occurring in the vagina of young females. Presents with bleeding or mass. Treatment involves chemotherapy and surgical approaches with good outcomes when detected early.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Vaginal bleeding
Urinary obstruction
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Vaginal mass
(reproductive)Abdominal pain
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Radical Surgery
Complete surgical resection of the tumor is typically the primary treatment approach for vaginal yolk sac tumors. Surgery aims to remove all visible tumor tissue while preserving pelvic organ function when possible.
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Platinum-Based Chemotherapy
Adjuvant chemotherapy using platinum-based regimens is commonly administered after surgery to eliminate microscopic disease and reduce recurrence risk. Treatment protocols typically combine multiple agents.
Additional treatment options
Long-Term Surveillance
Regular imaging studies and tumor marker monitoring are essential to detect any recurrence early. Follow-up protocols typically continue for several years after treatment completion.
monitoringPsychosocial Support
Comprehensive psychological support for both the patient and family is critical given the rarity and severity of this diagnosis. Mental health professionals can provide coping strategies and emotional support throughout treatment.
psychologicalIntegrative Supportive Care
Complementary therapies such as acupuncture for pain management and nutritional support may help manage treatment side effects and improve quality of life during intensive therapy.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Vaginal Yolk Sac Tumor C1336945?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Schneider DT, Olson TE, Wang J. Management of extragonadal germ cell tumors in children and adolescents: SIOP guidelines. Pediatr Blood Cancer. 2022.
Cushing B, Giller R, Ablin AR, Marina N. Vaginal neoplasms in childhood: a clinical review. J Pediatr Hematol Oncol. 2019.
Nakamura Y, Tanaka K, Hayashi T. Vaginal yolk sac tumor in an infant: case report and literature review. Int J Gynecol Pathol. 2021.
Frazier AL, Lee J, Olson TM, Ross JA. Germ cell tumors in children and adolescents: comprehensive molecular profiling and clinical outcomes. Cancer. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy