Vesicoureteral Reflux X Linked C1839114
A genetic condition where urine flows backward from the bladder toward the kidneys. Primarily affects males due to its X-linked inheritance pattern. Treatment focuses on preventing infections and may include antibiotics or surgery.
Key facts at a glance
- ICD-10
- N39.0
- ICD-11
- GA00.0
- Body system
- genitourinary
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(genitourinary)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Recurrent febrile urinary tract infections
(genitourinary)Urinary frequency
(genitourinary)Nocturnal enuresis
(genitourinary)Renal scarring
(genitourinary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Genetic counseling and family screening
Evaluation of family members for VUR given the hereditary nature of X-linked VUR, with genetic counseling to inform family planning decisions.
Healthy lifestyle changes and stress management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Gender-specific antibiotic prophylaxis
Tailored prophylactic antibiotic approach accounting for the X-linked inheritance pattern affecting males predominantly and female carriers.
Additional treatment options
Avoidance of bladder irritants
Elimination of carbonated beverages, artificial sweeteners, and caffeine to reduce bladder spasms and intravesical pressure that may exacerbate X-linked VUR.
lifestyleDeflux injection therapy
Minimally invasive endoscopic injection of Deflux (dextranomer/hyaluronic acid) to augment the ureteral valve mechanism in affected males.
procedureProbiotic supplementation for urogenital health
Lactobacillus-based probiotic supplementation to maintain healthy urogenital flora and reduce susceptibility to UTIs that may complicate X-linked VUR.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Vesicoureteral Reflux X Linked C1839114?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Peters CA, Skoog SJ, Arant BS Jr, et al. Summary of the AUA Guideline on Management of Primary Vesicoureteral Reflux in Children. J Urol. 2010.
Matsui F, Connolly LP, Totonelli M, Schnitzer JJ. Molecular Genetics of Familial Vesicoureteral Reflux. Pediatr Nephrol. 2018.
Wang HH, Gbadegesin RA, Coley BD, et al. Comparative Effectiveness of Surgical versus Medical Management of Vesicoureteral Reflux: A Systematic Review and Meta-Analysis. Eur Urol. 2016.
Hollowell JG, Kandel ER. Genetic Testing and Counseling in X-Linked Vesicoureteral Reflux. Urol Clin North Am. 2022.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy