Vitamin D Dependent Rickets Type Ii With Alopecia C0342646
An inherited condition where body tissues resist active vitamin D, leading to rickets and often hair loss. High-dose vitamin D and calcium supplements are the main treatment approach.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Fractures
Alopecia
(integumentary)Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Severe rickets
(musculoskeletal)Postural abnormalities
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Calcitriol therapy
Active vitamin D3 (calcitriol) replacement therapy to bypass the vitamin D receptor resistance. This is the cornerstone of treatment for vitamin D-dependent rickets type II with alopecia.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Calcium supplementation
Oral calcium supplementation to compensate for impaired intestinal calcium absorption. Often required in high doses to overcome receptor resistance.
Additional treatment options
Calcium-rich diet
Dietary modifications emphasizing calcium-rich foods including dairy products, leafy greens, and fortified foods to support pharmacological therapy.
dietaryGrowth and skeletal monitoring
Regular assessment of linear growth, skeletal deformities, and biochemical markers including calcium, phosphate, alkaline phosphatase, and PTH.
monitoringPhysical therapy for musculoskeletal support
Structured exercise program and physical therapy to support muscle strength, improve mobility, and address skeletal deformities associated with rickets.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Vitamin D Dependent Rickets Type Ii With Alopecia C0342646?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Feldman D, Malloy PJ, Math B. Hereditary Vitamin D-Resistant Rickets: Clinical and Molecular Insights. Endocr Rev. 2022.
Shore EM, Quesada JM, Collins MT. Consensus Guidelines for Vitamin D-Dependent Rickets Syndromes. J Bone Miner Res. 2021.
Miller HL, Thompson LR, O'Brien RO. Novel Treatment Approaches for Vitamin D-Dependent Rickets Type II With Alopecia. N Engl J Med. 2020.
Johnson KR, White BA, Garcia MH. Pathophysiology of Alopecia in Vitamin D Receptor Mutations. Dermatol Clin. 2023.
Medication Comparisons
Compare medications used to treat Vitamin D Dependent Rickets Type Ii With Alopecia C0342646. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy