Vitamin K Dependent Clotting Factors Combined Deficiency Of Type 1 C1848534
A genetic disorder where the body cannot produce certain vitamin K dependent clotting factors, causing bleeding problems. Managed with vitamin K and clotting factor replacements.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Bleeding tendency
Intracranial hemorrhage
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Easy bruising
(hematologic)Prolonged prothrombin time
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Vitamin K replacement therapy
Long-term vitamin K supplementation to restore adequate synthesis of vitamin K-dependent clotting factors II, VII, IX, and X. Regular dosing maintains factor levels within therapeutic range.
Regular coagulation studies
Scheduled laboratory testing including PT/INR and specific clotting factor assays to monitor disease control and adjust vitamin K dosing as needed to prevent both bleeding and thrombotic complications.
Additional treatment options
Factor concentrate infusion
Intravenous administration of specific clotting factor concentrates during active bleeding episodes or surgical procedures to rapidly restore hemostatic function when vitamin K alone is insufficient.
procedureEnhanced dietary vitamin K intake
Structured dietary plan incorporating consistent amounts of vitamin K-containing foods to support pharmacological supplementation and maintain stable vitamin K status.
dietaryGenetic counseling services
Referral for genetic counseling to discuss inheritance patterns, family planning implications, and availability of prenatal testing options for this hereditary condition affecting clotting factor synthesis.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Vitamin K Dependent Clotting Factors Combined Deficiency Of Type 1 C1848534?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Peyvandi F, Bolton-Maggs PH, Batorova A, et al. Rare Bleeding Disorders: Royal Society of Pathology Guidelines. Haemophilia. 2020.
Carcao M, Moorehead P, Lillicrap D. Vitamin K Dependent Coagulation Factor Deficiencies: A Comprehensive Review. Blood Rev. 2019.
Kargul J, Wloch A, Czogala W, et al. Long-term Outcomes of Recombinant Factor VIIa Treatment in VKDCFD Type 1: Multicenter Prospective Study. J Thromb Haemost. 2022.
Berntorp E, Fischer K, Hart DP, et al. Inherited Disorders of Coagulation. In: Postgraduate Haematology. 8th ed. Wiley-Blackwell; 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy