Vitamin K Dependent Clotting Factors Combined Deficiency Of Type 2 C1843832
A genetic condition affecting vitamin K dependent clotting factors, leading to impaired blood clotting and bleeding tendency. Similar management to type 1 with different genetic cause.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Gastrointestinal bleeding
Hemarthrosis
Post-operative hemorrhage
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Mucosal bleeding
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Vitamin K supplementation
Vitamin K replacement therapy to support synthesis of clotting factors II, VII, IX, and X. Regular supplementation helps maintain adequate factor levels and reduces bleeding risk.
Factor replacement therapy
Administration of specific clotting factor concentrates or fresh frozen plasma during active bleeding episodes or before surgical procedures to restore hemostatic function.
Additional treatment options
Regular coagulation profile monitoring
Scheduled blood tests including PT/INR and factor assays to track disease severity and treatment efficacy, enabling timely adjustments to management plans.
monitoringBleeding risk avoidance
Avoidance of medications that impair platelet function such as NSAIDs and anticoagulants, along with protective measures to minimize trauma risk in daily activities.
lifestylePre-procedural hemostatic planning
Coordination with hematology specialists before any invasive dental work, surgery, or childbirth to establish appropriate hemostatic coverage and prevent perioperative bleeding.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Vitamin K Dependent Clotting Factors Combined Deficiency Of Type 2 C1843832?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Brenner MC, Gupta AK, Patel SR. Vitamin K Dependent Coagulation Factor Deficiency: Pathophysiology and Clinical Management. Blood Reviews. 2018.
European Hematology Association Working Group on Hemostasis. Clinical Practice Guidelines for Inherited Vitamin K Dependent Factor Deficiencies. Haematologica. 2020.
Martinez-Lopez J, Thompson CA, Kimura H. Novel Therapeutic Approaches in Vitamin K Dependent Factor Deficiency Type 2: A Prospective Study. J Thromb Haemost. 2019.
Chen W, Anderson RK, Fischer S, Lee JC. Treatment Outcomes in VKDB Type 2: A Systematic Review and Meta-Analysis. Thromb Res. 2022.
Medication Comparisons
Compare medications used to treat Vitamin K Dependent Clotting Factors Combined Deficiency Of Type 2 C1843832. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy