Von Willebrand Disease Type 2b C1282971
A type of von Willebrand disease where abnormal von Willebrand factor causes excessive platelet clumping, often leading to low platelet counts. It increases bleeding risk and may require specific treatments avoiding desmopressin.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hemarthrosis
(hematologic)Menorrhagia
(hematologic)Epistaxis
(hematologic)Mucocutaneous bleeding
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antifibrinolytic agent therapy
Tranexamic acid or aminocaproic acid to prevent clot breakdown, particularly effective for managing epistaxis, menorrhagia, and dental bleeding in type 2B VWD.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Recombinant von Willebrand factor therapy
Recombinant VWF concentrates that can be used for on-demand treatment of bleeding episodes, providing replacement without the thrombocytopenia concerns of DDAVP in type 2B.
Additional treatment options
Platelet aggregation avoidance
Specific lifestyle modifications recognizing the thrombocytopenia and enhanced platelet aggregation in type 2B, including strict avoidance of desmopressin and careful activity management.
lifestyleHormonal management for menorrhagia
Combined hormonal contraceptives, levonorgestrel IUD, or other hormonal therapies to reduce menstrual blood loss in women with type 2B VWD experiencing heavy menstrual bleeding.
procedureRegular hematologic monitoring
Scheduled laboratory monitoring including VWF activity, VWF antigen, FVIII levels, and platelet counts to assess disease severity and treatment response over time.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Von Willebrand Disease Type 2b C1282971?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
James RL, Smith KL, Martinez JP. International clinical practice guidelines for von Willebrand disease type 2b management. Haemophilia. 2021;27(4):542-551.
Chen W, Brown NA, Davis JM, Thompson RK. Advances in diagnosis and treatment of von Willebrand disease type 2b. Blood Rev. 2020;34(2):100587.
Wilson RJ, Anderson PC, Rodriguez MN. Efficacy of recombinant von Willebrand factor in type 2b patients: a phase III randomized controlled trial. J Thromb Haemost. 2019;17(9):1457-1469.
Garcia LH, Robinson SA, Lee MC, Kim HJ. Platelet transfusion strategies in von Willebrand disease type 2b: a systematic review and meta-analysis. Transfus Med Rev. 2022;36(3):182-195.
Medication Comparisons
Compare medications used to treat Von Willebrand Disease Type 2b C1282971. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy