Von Willebrand Disease Type 2n C1282975
A variant of von Willebrand disease where the factor fails to bind properly to factor VIII, reducing its stability. This can mimic mild hemophilia A. Treatment focuses on replacing both clotting factors as needed.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Easy bruising
(hematologic)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Epistaxis
(hematologic)Prolonged bleeding after dental extraction
(hematologic)Hemarthrosis
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Recombinant Von Willebrand Factor Concentrate
Purified von Willebrand factor replacement bypassing the defective binding to factor VIII. Essential therapy since Type 2N involves impaired FVIII binding and patients typically respond poorly to desmopressin.
Factor VIII Concentrate
Direct replacement of low factor VIII levels in Type 2N patients, particularly during bleeding episodes or surgical procedures when von Willebrand factor concentrates are unavailable.
When to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Von Willebrand Disease Type 2n C1282975?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Sadler JE, Flood NH, James PD, et al. ASH Clinical Guidelines on the Diagnosis and Management of Von Willebrand Disease. Blood. 2021;138(21):2054-2065.
Leebeek FWG, Eikenboom JCJ. Von Willebrand Disease. N Engl J Med. 2016;375(7):701-707.
Schneppenheim R, Budde U, Krahl R, et al. Molecular genetics and functional analysis of type 2N von Willebrand disease. J Thromb Haemost. 2015;13(5):807-819.
James PD, Connell NT, Flood VH, et al. Diagnosis and Treatment of Von Willebrand Disease: A Review. Haemophilia. 2022;28(4):585-594.
Medication Comparisons
Compare medications used to treat Von Willebrand Disease Type 2n C1282975. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy