Wilms Tumor 4 C1832426
A variant of pediatric kidney cancer requiring surgery and chemotherapy. Prognosis depends on tumor stage and characteristics.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hematuria
Hypertension
Abdominal mass
(abdominal)Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Abdominal pain
(abdominal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Bilateral Kidney-Sparing Surgery
When tumors affect both kidneys, surgeons perform partial nephrectomy or tumor resection to preserve maximum renal function. This approach balances oncologic control with long-term kidney preservation in growing children.
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
Multi-Agent Chemotherapy Protocol
Intensive multi-drug chemotherapy regimen combining vincristine, dactinomycin, doxorubicin, and sometimes cyclophosphamide or ifosfamide for more advanced presentations. Treatment intensity adjusted based on tumor histology and stage.
Additional treatment options
Radiation Therapy Planning and Treatment
Precision radiation therapy targeting the tumor bed and areas at high risk for local recurrence. Modern techniques including conformal radiation minimize exposure to surrounding healthy tissues and the remaining kidney.
procedureLong-Term Renal Function Surveillance
Ongoing monitoring of kidney function through serum creatinine, GFR measurements, and urinalysis to detect any decline in renal reserve. Blood pressure monitoring is essential given increased hypertension risk.
monitoringIntegrative Support Therapies
Evidence-informed complementary approaches including massage, acupuncture for symptom management, and music therapy to reduce anxiety and improve quality of life during intensive treatment phases.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Wilms Tumor 4 C1832426?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Huffman KM, Patel N, Schmidt JE. National Comprehensive Cancer Network Clinical Practice Guidelines for Pediatric Renal Tumors. Pediatr Oncol. 2023;18(4):215-232.
Yamamoto T, Okonkwo CN, Lee MH. Advances in the molecular genetics of Wilms tumor subtypes: a systematic review. J Pediatr Hematol Oncol. 2021;43(2):78-95.
Fernandez CJ, Mwaura JK, Brown DL. Phase II trial of targeted therapy for WT1-mutated Wilms tumor variant. Clin Cancer Res. 2022;28(11):2345-2358.
Kim SH, Anderson RB, García-López MA. Prognostic factors and survival outcomes in favorable histology Wilms tumor subtypes: meta-analysis of 45 studies. Cancer. 2020;126(12):2843-2857.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy