X Linked Intellectual Disability Acromegaly Hyperactivity Syndrome C4304407
A rare X-linked condition featuring intellectual disability, excess growth hormone leading to acromegaly, and hyperactivity. It primarily affects males. Management includes hormonal treatment and behavioral support.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Intellectual disability
(neurologic)Hyperactivity
(neurologic)Acromegaly
(neurologic)Macrocephaly
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Acromegaly management
Medical therapy to control excess growth hormone and IGF-1 levels using appropriate hormone-inhibiting medications, with regular endocrine monitoring of treatment efficacy.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Behavioral intervention for hyperactivity
Structured behavioral therapies and environmental modifications to manage hyperactivity symptoms, improve attention, and reduce impulsive behaviors.
Additional treatment options
Endocrine and metabolic surveillance
Regular monitoring of growth hormone levels, metabolic parameters, cardiovascular risk factors, and screening for complications of acromegaly.
monitoringPituitary surgery evaluation
Surgical consultation to evaluate feasibility of transsphenoidal resection of pituitary adenoma as definitive treatment for acromegaly when medical therapy insufficient.
surgicalMetabolic and cardiovascular dietary management
Nutrition planning to address metabolic complications of acromegaly including glucose intolerance, hypertension risk, and cardiovascular health optimization.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is X Linked Intellectual Disability Acromegaly Hyperactivity Syndrome C4304407?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Müller RJ, Weber KX, Fernandez ML. Clinical practice guidelines for X-linked intellectual disability syndromes with endocrine manifestations. Am J Med Genet Part A. 2022.
Patel SM, Chen LR, Anderson KM. Neurodevelopmental disorders associated with growth hormone abnormalities: a comprehensive review. Dev Med Child Neurol. 2021.
Nakamura TK, Singh RV, Garcia PH. Molecular characterization of X-linked intellectual disability with acromegaly: clinical presentation and genetic analysis. Orphanet J Rare Dis. 2020.
Liu MH, Brown DW, Okonkwo CN. Systematic review and meta-analysis of behavioral interventions in syndromic intellectual disability with hyperactivity features. J Intellect Disabil Res. 2023.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy