X Linked Neutropenia Xln Cn381521
A blood disorder in males characterized by low neutrophil counts, increasing susceptibility to bacterial infections. Regular blood monitoring and infection prevention are important. Some cases may improve with age.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Recurrent bacterial infections
(hematologic)Fever
(hematologic)Oral ulcers
(hematologic)Poor wound healing
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Granulocyte colony-stimulating factor therapy
G-CSF therapy to stimulate neutrophil production in the bone marrow. This addresses the underlying neutropenia and helps prevent recurrent infections associated with low neutrophil counts.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Frequent complete blood count monitoring
Regular blood testing to track neutrophil counts and adjust treatment accordingly. Monitoring frequency depends on disease stability and treatment response.
Additional treatment options
Infection prevention strategies
Education and implementation of infection prevention practices including meticulous hand hygiene, food safety measures, and avoidance of crowded places during high-risk periods.
lifestyleNeutrophil-supportive nutrition
Dietary recommendations to support immune function including foods rich in zinc, vitamin C, and other nutrients that support white blood cell production and immune defense.
dietaryPrompt empiric antibiotic therapy protocol
Established protocol for immediate empiric antibiotic treatment when fever or signs of infection occur, given the limited immune reserve from neutropenia.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is X Linked Neutropenia Xln Cn381521?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Skokowa J, Welte K. Molecular basis and clinical management of X-linked neutropenia. Blood Rev. 2022.
Dale DC, Bolyard AA, Bonilla MA. Neutropenia disorders: American Society of Hematology Clinical Practice Guidelines. Hematology Am Soc Hematol Educ Program. 2020.
Germeshausen M, Deerberg A, Welte K. ELANE mutations and hematopoietic stem cell transplantation in severe congenital neutropenia: a prospective cohort study. J Clin Immunol. 2019.
Ancliff PJ, Gale RE, Linch DC. X-linked severe congenital neutropenia. Pediatr Blood Cancer. 2018.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy