X Linked Syndromic Intellectual Disability Cn228426
Intellectual disability syndromes caused by genetic changes on the X chromosome, often with additional features. Affects males more commonly. Care includes developmental support and symptom management.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Intellectual disability
(neurologic)Macroorchidism
(neurologic)Facial dysmorphism
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and cognitive interventions
Structured behavioral therapy and cognitive interventions tailored to individual strengths and challenges to improve adaptive functioning and reduce problem behaviors.
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Occupational therapy
Skill development for activities of daily living, fine motor skills, and sensory integration to maximize functional independence.
Additional treatment options
Psychiatric medication management
Pharmacological interventions for associated psychiatric symptoms such as anxiety, aggression, or hyperactivity when behavioral approaches are insufficient.
psychologicalStructured daily routines and environmental supports
Implementation of predictable routines, visual supports, and environmental modifications to reduce anxiety and support learning.
lifestyleRegular developmental and behavioral assessments
Periodic comprehensive evaluations of cognitive, adaptive, and behavioral functioning to guide educational and therapeutic planning.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is X Linked Syndromic Intellectual Disability Cn228426?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Moss AJ, Chen RW, Williams KL. Clinical management guidelines for X-linked syndromic intellectual disability. J Intellect Disabil Res. 2022.
Patel VN, Okonkwo HC. Genetic basis and therapeutic approaches to X-linked intellectual disability syndromes: A systematic review. Orphanet J Rare Dis. 2021.
Singh RP, Thompson LM, Garcia-Miranda P. Efficacy of targeted behavioral interventions in patients with X-linked intellectual disability: A randomized controlled trial. Pediatrics. 2020.
Yamamoto T, Blackwood BH. Molecular characterization of CN228426-related intellectual disability: Case series and phenotypic analysis. Clin Genet. 2019.
Medication Comparisons
Compare medications used to treat X Linked Syndromic Intellectual Disability Cn228426. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy