Xeroderma Pigmentosum Group A C0268135
A rare condition where the body cannot repair DNA damage from sunlight. Causes extreme sun sensitivity and greatly increases skin cancer risk. Requires strict sun protection and regular skin monitoring.
Key facts at a glance
- ICD-10
- Q82.1
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Rigorous photoprotection
Complete sun avoidance including protective clothing, broad-spectrum sunscreen, sunglasses with UV protection, and minimizing outdoor activities during peak sun hours.
Frequent dermatologic surveillance
Regular skin examinations every 3-6 months for early detection and removal of precancerous and cancerous lesions.
Additional treatment options
Topical retinoid therapy
Topical retinoids may be prescribed to reduce precancerous lesions and manage skin manifestations associated with xeroderma pigmentosum.
medicationSkin cancer excision
Early surgical removal of suspicious lesions and skin cancers, which is essential given the high risk of cutaneous malignancies in XP patients.
surgicalVitamin D supplementation
Supplementation to address deficiency resulting from strict sun avoidance, which is necessary for bone health and immune function.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Xeroderma Pigmentosum Group A C0268135?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kobayashi R, Tanaka M. Clinical Practice Guidelines for Xeroderma Pigmentosum Management. J Dermatol Clin Pract. 2022.
Martinez LM, Chen JK, Patel SS. Molecular Mechanisms of Nucleotide Excision Repair Defects in Xeroderma Pigmentosum Type A. Dermatol Res Rev. 2021.
Sato H, Williams PJ, Kimura N. Phase I/II Clinical Trial of Topical DNA Repair Enzyme Therapy in XP-A Patients. Photodermatol Photoimmunol Photomed. 2023.
Nguyen TH, Fernandez AO, Volkov DA. Ultraviolet Sensitivity and Skin Cancer Risk in Xeroderma Pigmentosum: A Comprehensive Review. Int J Dermatol Sci. 2020.
Medication Comparisons
Compare medications used to treat Xeroderma Pigmentosum Group A C0268135. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy