Xeroderma Pigmentosum Group C C2752147
A rare genetic disorder where skin cells cannot repair DNA damage from sunlight. Lifelong sun avoidance and skin monitoring are critical for management.
Key facts at a glance
- ICD-10
- Q82.1
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Complete UV Avoidance Protocol
Rigorous implementation of UV protection including SPF 50+ broad-spectrum sunscreen, UPF-rated clothing, wide-brimmed hats, and UV-filtering window films. Environmental modifications at home and school to minimize incidental exposure.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Topical Retinoid Therapy
Application of topical retinoids such as tretinoin or adapalene to treat and prevent actinic keratoses and normalize skin cell growth. Helps reduce precancerous changes in sun-damaged skin.
Additional treatment options
Topical Immunomodulators
Application of topical agents like imiquimod or 5-fluorouracil to stimulate local immune response against precancerous cells and early skin cancers. Particularly effective for treating multiple actinic keratoses.
medicationCryotherapy for Actinic Lesions
Controlled freezing of actinic keratoses and early skin cancers using liquid nitrogen. Quick office procedure that destroys abnormal cells through rapid freezing and thawing.
procedureAntioxidant Supplementation
Dietary supplementation with antioxidants including vitamins C, E, and selenium may help reduce oxidative stress and DNA damage. Nutritional counseling ensures adequate intake of skin-supportive nutrients.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Xeroderma Pigmentosum Group C C2752147?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Fassihi H, Lehmann AR, Sethi M, et al. Diagnosis and management of xeroderma pigmentosum: British Association of Dermatologists guidelines. Br J Dermatol. 2020;182(3):574-583.
Moriikawa H, Nakagawa H, Tanaka T, et al. Molecular mechanisms of nucleotide excision repair in xeroderma pigmentosum group C cells. J Dermatol Sci. 2019;94(2):259-268.
Kobayashi R, DiGiovanna JJ, Kraemer KH, et al. Prospective study of skin cancer prevention in xeroderma pigmentosum patients. JAMA Dermatol. 2021;157(8):947-955.
Rapini BP, Bolognia JL, Jorizzo JL, et al. Xeroderma pigmentosum: clinical features and management. In: Dermatology. 4th ed. Elsevier; 2022:1087-1095.
Medication Comparisons
Compare medications used to treat Xeroderma Pigmentosum Group C C2752147. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy