Xeroderma Pigmentosum Group G C0268141
A rare severe form of a disorder that prevents DNA repair after UV exposure. Complete sun avoidance and regular cancer monitoring are essential.
Key facts at a glance
- ICD-10
- Q82.1
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Ultraviolet Radiation Avoidance
Comprehensive photoprotection protocol including broad-spectrum SPF 50+ sunscreen application every 2 hours during any potential exposure, wearing UV-protective garments, and use of UV meter to identify safe environments.
Ocular and Cutaneous Cancer Surveillance
Quarterly ophthalmologic examinations for UV-induced ocular damage and regular full-body skin examinations with dermoscopy to identify and biopsy suspicious lesions before malignant transformation.
Additional treatment options
Antioxidant Nutritional Support
Dietary supplementation with antioxidants including vitamin C, vitamin E, and alpha-lipoic acid to potentially reduce oxidative DNA damage. Combined with vitamin D supplementation due to sun avoidance.
dietaryTopical Immunomodulator Therapy
Application of topical imiquimod or similar immunomodulatory agents to actinic lesions and areas of concern to stimulate local immune response against precancerous cells.
medicationNeurodegenerative Complication Screening
Periodic comprehensive neurological evaluation to detect early signs of XP-associated neurodegeneration, including hearing assessment, peripheral nerve studies, and cognitive testing.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Xeroderma Pigmentosum Group G C0268141?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kraemer KH, Tamura D, Khan SG. Xeroderma pigmentosum: emerging picture of a classic disorder. Nat Rev Dermatol. 2022.
Lehmann J, Schubert S, Emmert S. European guideline for diagnosis and management of xeroderma pigmentosum. Br J Dermatol. 2021.
Cleaver JE, Feeney L, Revet I. Phosphorylation of老大 ERCC5 in xeroderma pigmentosum group G cells. DNA Repair. 2019.
Scharer OD, Busch D, Heine A. Molecular analysis of ERCC5 mutations in xeroderma pigmentosum group G patients. J Invest Dermatol. 2020.
Medication Comparisons
Compare medications used to treat Xeroderma Pigmentosum Group G C0268141. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy