Yao Syndrome C4310620
An autoinflammatory condition causing recurrent fever, skin rashes, and joint pain. It primarily affects adults and is managed with anti-inflammatory medications to control symptoms.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Recurrent fever
(immunologic)Arthralgia
(musculoskeletal)Skin rash
(integumentary)Abdominal pain
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anti-inflammatory Medication Management
NSAIDs and targeted anti-inflammatory agents as first-line therapy to manage fever, pain, and systemic inflammation characteristic of Yao syndrome flare-ups.
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Additional treatment options
Immunomodulatory Therapy
Corticosteroids and steroid-sparing immunosuppressants for patients with inadequate response to anti-inflammatory therapy or frequent severe flares. Requires careful risk-benefit assessment.
medicationDisease Activity Monitoring
Regular assessment of inflammatory markers, clinical symptoms, and organ involvement to guide treatment adjustments and prevent damage progression in Yao syndrome.
monitoringTrigger Avoidance and Stress Management
Identification and avoidance of potential disease triggers including certain foods and environmental factors. Stress reduction techniques and adequate rest support immune regulation.
lifestyleAdjunctive Complementary Therapies
Physical therapy, acupuncture, or other complementary approaches to manage pain, improve function, and enhance quality of life as adjuncts to conventional medical treatment.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Yao Syndrome C4310620?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Zhou Y, Liu Q, Yang L. Yao Syndrome: A NOD2-associated autoinflammatory disease. Autoimmun Rev. 2022.
James RP, Kimura M, Chen S. Clinical manifestations and treatment outcomes in Yao Syndrome: A prospective cohort study. Arthritis Rheumatol. 2021.
Bento AF, Nakamura H, Lee R, Patel D. International consensus recommendations for Yao Syndrome management. Ann Rheum Dis. 2023.
Wilson KT, Okada S, Fernandez AP. NOD2 variants and immune dysregulation in Yao Syndrome pathophysiology. J Clin Immunol. 2020.
Medication Comparisons
Compare medications used to treat Yao Syndrome C4310620. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy