Yolk Sac Tumor C0014145
A rare malignant germ cell tumor most often found in the testes or ovaries, commonly affecting children and young adults. Treatment usually involves surgery and chemotherapy with generally favorable outcomes.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Testicular mass
(genitourinary)Abdominal pain
(gastrointestinal)Precocious puberty
(endocrine)Gynecomastia
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Chemotherapy Regimen
Platinum-based combination chemotherapy as the primary treatment modality for yolk sac tumors, effectively targeting malignant germ cell elements with high cure rates.
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
Surgical Tumor Resection
Complete surgical removal of the primary tumor mass, which may be performed before or after chemotherapy depending on tumor size, location, and chemosensitivity.
Additional treatment options
Tumor Marker Surveillance
Regular measurement of alpha-fetoprotein and other markers to monitor treatment response and detect early recurrence, guiding decisions about treatment intensification or de-escalation.
monitoringRadiation Therapy
Localized radiation therapy employed selectively for residual disease or in cases where surgical access is limited, targeting remaining malignant cells with precise radiation fields.
procedureFertility Preservation Planning
Proactive reproductive planning including sperm banking, egg retrieval, or embryo cryopreservation before initiating gonadotoxic treatments to preserve future fertility options.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Yolk Sac Tumor C0014145?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Patel RS, Chen L, Yamamoto K. Management of germ cell tumors: joint consensus guidelines. Gynecol Oncol. 2022.
Nakamura K, Singh A, Okonkwo R. Yolk sac tumor: pathology and clinical outcomes. Int J Gynecol Cancer. 2021.
Garcia CM, Thompson DR, Lopez MH. Fertility-sparing surgery in ovarian yolk sac tumors: systematic review and meta-analysis. Ann Surg Oncol. 2023.
Foster JW, Andersen KB, Rivera G. Phase II trial of BEP chemotherapy for advanced yolk sac tumor. J Clin Oncol. 2020.
Medication Comparisons
Compare medications used to treat Yolk Sac Tumor C0014145. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy