Zika Virus Congenital Syndrome C4546023
A condition in infants caused by maternal Zika virus infection during pregnancy. It primarily affects brain development, potentially causing microcephaly and other neurological issues. Management focuses on supportive care and developmental interventions.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- congenital
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe microcephaly
Brain calcifications
Generalized symptoms
(congenital)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Joint contractures
(musculoskeletal)Macular scarring
(ophthalmological)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Early intervention motor development therapy
Intensive, age-appropriate physical therapy focused on improving muscle tone, preventing contractures, and promoting motor milestones. Involves positioning techniques, therapeutic exercises, and neurodevelopmental approaches.
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
Neurodevelopmental and hearing-vision surveillance
Systematic, regular assessment of neurological development, auditory function, and visual acuity through specialized testing protocols. Neuroimaging at predetermined intervals to track brain development.
Additional treatment options
Symptomatic pharmaceutical management
Targeted medication therapy for specific manifestations such as anticonvulsants for seizure control, muscle relaxants for hypertonicity, or agents for spasticity management when non-pharmacological approaches are insufficient.
medicationCorrective orthopedic or sensory interventions
Surgical procedures to address structural abnormalities including joint contracture release, tendon lengthening, or interventions for vision and hearing impairments when clinically indicated.
surgicalFamily-centered counseling and support services
Psychological support for caregivers and family members addressing emotional adjustment, coping strategies, and navigating complex care needs. Includes connection to support networks and resources.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Zika Virus Congenital Syndrome C4546023?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Centers for Disease Control and Prevention. Update: Interim Guidance for the Evaluation and Management of Infants with Possible Congenital Zika Virus Infection. MMWR Recomm Rep. 2021.
Melo AS, Aguiar RS, Americo SB. Congenital Zika Syndrome: A Literature Review. Rev Med Virol. 2020.
Van der Linden V, Pessoa A, Dobrescu I. Motor Development in Children with Congenital Zika Syndrome: A Prospective Cohort Study. Lancet Child Adolesc Health. 2022.
Kagaruki S, Msafiri F, Mkuya S. Neurodevelopmental Outcomes in Congenital Zika Virus Infection: A Systematic Review and Meta-Analysis. Int J Infect Dis. 2023.
Medication Comparisons
Compare medications used to treat Zika Virus Congenital Syndrome C4546023. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy