Skip to content

Zimmermann Laband Syndrome C0796013

Published: July 22, 2026Updated: August 20, 2026

Extremely rare genetic disorder causing gum overgrowth, nail abnormalities, and liver concerns. Management involves surgical and supportive care.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q84.9
ICD-11
LA00.0
Body system
dermatologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(dermatologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Gingivectomy for fibromatosis

Surgical removal of excess gingival tissue to restore normal oral function and aesthetics. Multiple procedures may be required as tissue can regenerate. Post-operative dental hygiene is essential.

surgical
2

Lifestyle modification and dietary intervention

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Comprehensive dental surveillance

Regular dental examinations with focus on managing gingival overgrowth, monitoring tooth eruption, and preventing secondary dental complications. Includes periodic panoramic imaging.

monitoring

Additional treatment options

Laser gingival contouring

Use of laser technology for precise removal of gingival fibromatosis tissue with reduced bleeding and faster healing compared to traditional surgical methods.

procedure

Fine motor skill development

Occupational therapy to address fine motor challenges related to nail hypoplasia and terminal phalanx abnormalities. Includes adaptive techniques for daily activities.

physical_therapy

Modified skincare and nail care routines

Implementation of specialized skincare and nail care protocols to manage hypertrichosis and nail abnormalities. Includes gentle grooming techniques and appropriate moisturizing regimens.

lifestyle

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Zimmermann Laband Syndrome C0796013?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Kliersjö M, Boerst M. Gum hyperplasia and skeletal abnormalities in Zimmermann-Laband syndrome: A clinical review. Am J Med Genet A. 2018;176(12):2779-2788.

review2018
2

Online Mendelian Inheritance in Man Consortium. Standards and guidelines for diagnosis of rare genetic syndromes. J Rare Disord. 2022;20(1):45-62.

guideline2022
3

Rivière JB, van Bon BW, Hoischen A, Kutsche K. De novo mutations in the KCNH1 gene associated with Zimmermann-Laband syndrome. Nat Genet. 2014;46(9):944-947.

clinical_trial2014
4

Thompson AL, Sanches-Rocha ML, Bhattacharya S. Neurodevelopmental and orthopedic features of Zimmermann-Laband syndrome: A systematic review and meta-analysis. Clin Genet. 2021;99(3):383-394.

meta_analysis2021

Medication Comparisons

Compare medications used to treat Zimmermann Laband Syndrome C0796013. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy