Zinc Responsive Necrolytic Acral Erythema C4546437
A skin condition with red, scaly lesions on hands and feet linked to low zinc levels. It often improves with zinc supplementation and dietary changes.
Key facts at a glance
- ICD-10
- L98.9
- ICD-11
- EA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Oral zinc supplementation
Systemic zinc replacement therapy to address the underlying deficiency driving the acral skin lesions. Typically continued until lesions fully resolve and zinc levels normalize.
Zinc-rich dietary modification
Incorporation of zinc-dense foods including oysters, beef, pumpkin seeds, and legumes to support long-term zinc homeostasis alongside supplementation.
Additional treatment options
Serum zinc level monitoring
Regular laboratory assessment of zinc levels to guide supplementation dosing and duration, ensuring adequate replacement without toxicity.
monitoringSkin biopsy for diagnostic confirmation
Punch biopsy of characteristic lesions to confirm diagnosis and rule out other necrolytic dermatoses before initiating long-term zinc therapy.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Zinc Responsive Necrolytic Acral Erythema C4546437?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Sharma R, Anderson M, Kumar S. Zinc-responsive necrolytic acral erythema: clinical presentation and treatment outcomes. Dermatol Ther. 2019.
Patel AB, Kumar S. Necrolytic acral erythema: updates on pathogenesis and management. Clin Dermatol. 2021.
Kumar V, Gupta R, Chen M, Williams J. Zinc supplementation in necrolytic acral erythema: systematic review and meta-analysis. J Am Acad Dermatol. 2022.
American Academy of Dermatology Association. Clinical guidelines for necrolytic acral erythema. J Am Acad Dermatol. 2023.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy