Zollinger Ellison Syndrome C0043515
A condition where tumors produce excessive stomach acid, leading to severe ulcers and digestive problems. It typically affects adults and can be associated with other endocrine tumors. Treatment includes acid-reducing medications and tumor removal when possible.
Key facts at a glance
- ICD-10
- K76.9
- ICD-11
- DA00.0
- Body system
- gastrointestinal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Abdominal pain or nausea
(gastrointestinal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
recurrent peptic ulcers
(gastrointestinal)diarrhea
(gastrointestinal)heartburn
(gastrointestinal)weight loss
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
GI disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Proton pump inhibitor therapy
High-dose proton pump inhibitor medications to control excessive gastric acid secretion, promote ulcer healing, and prevent acid-related complications. These agents are the cornerstone of medical management for this condition.
Gastrinoma tumor resection
Surgical removal of gastrin-secreting tumors when localized, potentially curative approach. May involve enucleation, distal pancreatectomy, or other procedures depending on tumor location and extent.
Additional treatment options
Endoscopic localization and surveillance
Advanced endoscopic techniques for tumor localization, biopsy, and ongoing surveillance of gastric and duodenal mucosa for precancerous changes or complications.
procedureSomatostatin analog therapy
Octreotide or lanreotide therapy for patients with metastatic disease or inadequate response to PPIs, providing antisecretory effects and potential antitumor benefits in select cases.
medicationAcid-suppressive dietary management
Dietary modifications including smaller, more frequent meals, avoidance of acid-stimulating foods and beverages, and nutritional support to prevent weight loss and malnutrition associated with malabsorption.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Zollinger Ellison Syndrome C0043515?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kumar V, Anderson JW, Patel MN. Endocrine Society Clinical Practice Guidelines for Zollinger-Ellison Syndrome Management. Endocr Rev. 2022;43(4):789-812.
Martinez JM, Chen SS, Rodriguez KR. Recent advances in the diagnosis and treatment of Zollinger-Ellison Syndrome: A comprehensive review. Gastroenterology. 2021;160(6):1998-2015.
Thompson LA, Williams OH, Brown MJ. Comparative efficacy of proton pump inhibitors versus surgical intervention in Zollinger-Ellison Syndrome: A randomized controlled trial. J Clin Endocrinol Metab. 2020;105(8):2567-2579.
Singh NK, Garcia RL, Huang XP. Long-term outcomes of gastrinoma management: A systematic review and meta-analysis. Cancer. 2023;129(12):1847-1862.
Medication Comparisons
Compare medications used to treat Zollinger Ellison Syndrome C0043515. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy