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Serum or Plasma Substance Concentration for Serine Protease Inhibitor (e.g., Alpha-1 Antitrypsin variant or related protease inhibitor)

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of a protein that helps protect your lungs and liver from damage caused by enzymes released during inflammation or injury.

Quick summary

["This test helps assess risks for lung diseases like emphysema or liver problems related to protein imbalances."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
50075-1
Short code
11DC 1h p 250 ug ACTH SerPl-sCnc
Synonyms
11DC 1h p 250 ug ACTH SerPl-sCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
60
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

Your sample contains a specific type of protein that naturally inhibits enzymes that could harm your body’s tissues. This test quantifies how much of this protein is present in your blood, which can vary depending on genetic factors, health conditions, or medications.

Why It Matters in Your Health

High or low levels of this protein may indicate conditions like genetic disorders affecting lung or liver function, chronic inflammation, or certain metabolic issues. It’s often used alongside other tests to diagnose or monitor these conditions.

Common Reasons for Testing

Doctors may order this test if you have symptoms like persistent coughing, shortness of breath, or liver-related issues (e.g., jaundice, fatigue). It’s also used in research or specialized screening for inherited protein disorders.

Sample Collection and Preparation

A blood sample is drawn from your arm, typically in the morning after fasting. The blood is processed to separate serum or plasma, which is then sent to a lab for analysis. Avoid strenuous activity or certain medications before testing for best accuracy.

Reference range

NCBI: ACTH 10-60 pg/mLN/A

Specimen: serum

Typically collected in the morning (8-10 AM). Inform your provider if taking steroid medications.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Alpha-1 Antitrypsin or Related Protease Inhibitor Level

Frequently asked questions

How long will results take to get?
Results are usually available within 1–3 business days, depending on lab processing times. Your healthcare provider will discuss the findings with you during your follow-up visit.
What if my results are outside normal ranges?
If your levels are unusually high or low, it may signal an underlying condition requiring further testing or medical evaluation. Your doctor will interpret results in the context of your symptoms and medical history.
Do I need to prepare differently if I’m pregnant?
No special preparation is needed for pregnancy, but inform your doctor if you’re expecting or breastfeeding. Some protease inhibitors are used in pregnancy, so your provider may adjust testing timing or considerations.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy