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Total Protein with Albumin/GLOBulin Separation (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total protein in your blood and separates it into albumin and globulin fractions, which help assess protein balance and potential liver or kidney issues.

Quick summary

["Helps diagnose conditions affecting protein levels in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58910-1
Short code
11DC 2.5h p chal SerPl-mCnc
Synonyms
11DC 2.5h p chal SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Your body relies on proteins like albumin and globulins for many vital functions, including maintaining fluid balance, supporting immunity, and transporting nutrients. Abnormal levels can signal problems with organs like the liver, kidneys, or immune system.

What to Expect Before the Test

No special preparation is needed, but you may fast for 8–12 hours before if your lab requires it. Bring any medications or questions to your provider.

How the Test Works

A blood sample is drawn from a vein, typically in your arm. The sample is processed to separate proteins, which are then measured using specialized lab techniques.

Possible Results and Their Meaning

Low total protein or albumin may indicate liver disease, malnutrition, or kidney problems. High globulin levels could suggest chronic infections, autoimmune disorders, or inflammation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Protein profile

Frequently asked questions

Why did my doctor order this test?
Your doctor may recommend it if you have symptoms like unexplained weight loss, swelling, fatigue, or if they suspect liver/kidney issues. It’s also used in routine check-ups for certain populations.
What do my specific albumin/globulin results mean?
Your provider will interpret the results in relation to your overall health and symptoms. For example, very low albumin might mean fluid retention or poor nutrient absorption, while high globulins could signal chronic inflammation.
Can I eat or drink anything before this test?
Check with your lab or provider about fasting requirements. Some tests require no food/drink for 8–12 hours, while others allow water. Never skip this step without confirmation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy