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Serum or plasma mass concentration of total protein

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, including albumin and other proteins like globulins. Proteins are essential for maintaining fluid balance, supporting immunity, and transporting nutrients.

Quick summary

["Total protein helps assess overall health, detect kidney issues, or identify protein-losing conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
57505-0
Short code
11DC 2D p MTP SerPl-mCnc
Synonyms
11DC 2D p MTP SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It Matters in Your Health

Your body relies on proteins for many vital functions, including keeping fluids in the right places, fighting infections, and helping cells communicate. Blood protein levels can give clues about how well your organs are working, especially your kidneys or liver.

What Could Affect Your Results

Several factors may influence your protein levels, such as diet (high-protein foods like meat, dairy, or legumes), hydration status, chronic illnesses (like kidney disease or liver problems), or certain medications. Recent blood loss, dehydration, or severe infections can also temporarily change results.

Common Conditions Linked to Protein Levels

Low protein levels (hypoproteinemia) might signal kidney disease, liver failure, malnutrition, or conditions where your body loses protein (like severe diarrhea or vomiting). High protein levels could indicate dehydration, certain cancers, or overactive thyroid.

What to Expect During the Test

A simple blood draw is used to collect your serum or plasma. The sample is then analyzed to measure the total protein content. This test is quick and painless, usually done in a lab setting with minimal preparation needed beyond fasting if required by your doctor.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

Why might my doctor order this test?
Your doctor may check total protein levels if they suspect kidney disease (like nephrotic syndrome), liver problems, malnutrition, or conditions where your body loses protein. It can also help monitor chronic diseases or screen for hidden health issues.
How long will I need to prepare for this test?
Preparation depends on your doctor’s instructions. Some tests may require fasting for 8–12 hours before drawing blood, while others may not. Ask your healthcare provider about specific guidelines for your appointment.
What are the typical reference ranges for this test?
Reference ranges vary by lab and individual health. Generally, total protein levels in blood are often reported between 6.0 to 8.0 grams per deciliter (g/dL). Your actual range may differ, so results should always be interpreted by a healthcare professional based on your full medical picture.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy