Serum or Plasma Protein Electrophoresis by Bromocresol Green (BCG) Method

What This Test Measures

The test separates blood proteins into distinct bands—such as albumin, alpha, beta, and gamma globulins—using a technique that detects protein concentration variations. Bromocresol green is used to visualize these fractions, helping identify shifts in protein levels that may indicate disease.

Why It’s Ordered

Your healthcare provider may recommend this test if you have symptoms like unexplained weight loss, fatigue, swelling, or if tests suggest conditions like multiple myeloma, amyloidosis, or chronic liver disease. It’s also used as part of routine monitoring for certain diseases.

Common Conditions Linked to Abnormal Results

Abnormal results may signal conditions affecting protein production, such as multiple myeloma (a cancer of plasma cells), chronic liver disease, or certain autoimmune disorders. Low albumin could indicate malnutrition or kidney disease, while elevated gamma globulins may point to infections or immune disorders.

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in the arm. The blood is processed to separate serum or plasma, which is then analyzed. No special preparation is needed, but fasting may be advised depending on your provider’s instructions.