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Total Protein in Serum (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and other proteins like globulins.

Quick summary

["Your blood protein levels help assess overall health, kidney function, and hydration status."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58908-5
Short code
11DC 40M p chal SerPl-mCnc
Synonyms
11DC 40M p chal SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It Matters in Your Health

Protein is essential for many bodily functions, including transporting nutrients, maintaining fluid balance, and supporting immune responses. Low protein levels may indicate conditions like malnutrition, kidney disease, or liver problems, while high levels could suggest dehydration or certain inflammatory conditions.

What to Expect During the Test

A small blood sample is drawn from your arm. The test involves processing the serum portion of your blood to measure protein content using a specialized laboratory method.

Common Conditions Monitored

Healthcare providers often check total protein levels to diagnose or monitor conditions such as kidney disease, liver disease, malnutrition, or dehydration. It can also help evaluate the effectiveness of treatments for these conditions.

Factors That Can Affect Results

Several factors may influence your protein test results, including recent meals (especially high-protein foods), certain medications, dehydration, or chronic illnesses like kidney disease or infections.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

How often should I get this test?
The frequency of this test depends on your medical history, symptoms, and overall health. Your healthcare provider will determine the best timing based on your individual needs, such as routine check-ups, monitoring chronic conditions, or evaluating symptoms like fatigue, swelling, or unexplained weight changes.
What if my results are outside the normal range?
If your results are outside the normal range, your healthcare provider will discuss them with you in detail. They may recommend additional tests, lifestyle changes, or treatments to address potential underlying issues. Never interpret results independently—always rely on professional medical advice.
Does diet affect this test?
Yes, diet can influence protein levels. Consuming high-protein foods shortly before your test may slightly alter results. For best accuracy, follow your healthcare provider’s instructions, which may include fasting or timing your meal around the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy