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C-reactive protein (CRP) by nephelometry (high-sensitivity)

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when your body is fighting inflammation, often used to check for low-grade inflammation or infection.

Quick summary

["High-sensitivity CRP helps track subtle inflammation that may not show up with other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
1357-3
Short code
11DC p 750 mg MTP Q4h X 6 SerPl-mCnc
Synonyms
11DC p 750 mg MTP Q4h X 6 SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
8
Ref high
61
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82977
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test to monitor chronic conditions like heart disease, arthritis, or autoimmune disorders. It can also help assess risk for future health issues or guide treatment decisions.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood, similar to other blood tests. If you’re on blood thinners, let your doctor know before the test.

How the Results Are Used

Results help doctors compare your inflammation levels over time. Elevated levels may signal inflammation that needs management, while normal levels suggest your body is responding well to treatment.

Common Conditions Monitored

This test is often used alongside other blood work to evaluate conditions like cardiovascular risk, inflammatory diseases (e.g., rheumatoid arthritis), or infections.

Reference range

Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

CRP is a marker for systemic inflammation. High levels may indicate conditions like infections, autoimmune diseases, or chronic conditions like heart disease. It’s not diagnostic on its own but supports broader assessments.

Short name

High-Sensitivity CRP

Frequently asked questions

What does a high CRP level mean?
A high CRP level suggests inflammation is present in your body, which could be due to infection, an autoimmune condition, or other health issues. Your doctor will consider the context (symptoms, other tests) to guide next steps.
How often should I get this test?
Your doctor will determine how often you need this test based on your health needs. Some people get it yearly, while others may need it more frequently if they have ongoing conditions.
Can diet or exercise affect CRP levels?
Yes, lifestyle factors like diet, exercise, and stress can influence CRP levels. Eating anti-inflammatory foods, staying active, and managing stress may help lower CRP over time.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy