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Serum/plasma mass concentration of total protein

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood serum or plasma. Proteins are essential for maintaining healthy tissues, fluids, and immune function.

Quick summary

["Total protein helps assess overall health and detect conditions like kidney disease or malnutrition."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
1657-6
Short code
11DC SerPl-mCnc
Synonyms
11DC SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It’s Done

Your healthcare provider may order this test to check for conditions affecting protein levels, such as kidney disease, liver problems, or malnutrition. It can also help monitor treatments for these conditions or evaluate symptoms like swelling, rapid weight loss, or fatigue.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a broader blood panel. Wear comfortable clothing and avoid heavy exercise the day of your visit.

How the Test Works

A healthcare professional will draw blood from a vein in your arm. The blood sample is then sent to a lab, where it is analyzed to determine the total protein concentration in your serum or plasma.

What the Results Mean

Results are typically reported in grams per deciliter (g/dL). Low protein levels may indicate conditions like kidney disease or severe malnutrition, while very high levels could suggest conditions like multiple myeloma or severe dehydration.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal protein levels can signal underlying health issues. Low protein levels may reflect poor nutrient absorption, chronic kidney disease, or liver dysfunction. High levels could indicate conditions like inflammation, dehydration, or certain cancers. Regular monitoring helps track these conditions and guide treatment decisions.

Short name

Total Protein

Frequently asked questions

How often should I get this test?
The frequency depends on your health status. If you have a known condition like kidney disease or liver problems, your provider may recommend testing every few months or annually. Otherwise, this test is often part of routine check-ups or when symptoms suggest a need for evaluation.
What causes low or high protein levels?
Low protein levels can result from poor diet, kidney disease, liver failure, or conditions that prevent protein absorption in the gut. High protein levels may be due to dehydration, inflammation, certain cancers, or overactive thyroid. Lifestyle factors, medications, or underlying illnesses can also play a role.
Can I eat or drink before this test?
For most protein tests, you may need to fast for 8–12 hours before the blood draw. However, check with your provider or lab technician for specific instructions, as some tests may not require fasting.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy