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Serum/plasma mass concentration of total protein (electrochemical method)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps assess overall health, kidney function, and nutritional status.

Quick summary

["Your blood protein levels can signal kidney issues, liver problems, or hydration status."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
18351-7
Short code
11DC sp2 p chal SerPl-mCnc
Synonyms
11DC sp2 p chal SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Protein is essential for many bodily functions, including transporting nutrients, maintaining fluid balance, and supporting immune responses. Low levels may indicate conditions like malnutrition, kidney disease, or severe dehydration, while high levels could suggest conditions like multiple myeloma or liver disease.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the draw if your test involves a specific timing (e.g., 24-hour urine). Bring any medications or supplements you’re taking, as they may affect results.

Common Causes of Abnormal Results

Results may vary based on your health, diet, and medications. For example, kidney disease often leads to lower protein levels, while liver disease or dehydration may raise them. Always discuss any concerns with your healthcare provider.

How This Test Is Performed

A healthcare professional will draw blood from a vein in your arm. The sample is then sent to a lab for analysis using an electrochemical method to measure protein concentration.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein Level

Frequently asked questions

What might cause my protein levels to be too low?
Low protein levels can result from conditions like kidney disease, severe malnutrition, or liver problems. It may also occur if you’re losing protein through excessive sweating, wounds, or certain medications.
What might cause my protein levels to be too high?
High protein levels can be linked to conditions such as multiple myeloma (a blood cancer), liver disease, or dehydration. Rarely, it may also appear in cases of severe burns or dehydration from illness.
Do I need to avoid certain foods before this test?
No specific diet restrictions apply, but if your test involves a 24-hour urine collection, follow your provider’s instructions carefully. Avoid excessive protein intake if instructed, as it may skew results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy