14dioxaneairmcncMedically reviewed by WellAlly Editorial Team·Last reviewed August 16, 2026·[Editorial policy](https://wellally.tech/editorial-policy)
## Key facts at a glance
LOINC38593-0Short code1,4-DIOXSynonyms1,4Dioxane Air-mCncCategorychemistrySampleserumContainerSerum separator tube (SST) or plain red top tube; specific air sampling media (activated charcoal tubes or passive dosimeters) if air testingUnitsN/AFastingfalsePopulationadultSexallAge range18–65 yearsMethodGas chromatography-mass spectrometry (GC-MS) or Solid-phase microextraction (SPME) with GC-MS analysisCPT84600 (Volatile organic compound(s) analysis, not elsewhere specified) or 83018 (unspecified toxicology screen)SNOMED372729009 (1,4-Dioxane measurement) or 268651007 (Occupational exposure assessment)Specimen volume5-10 mL venous blood for serum; air volume depends on method (typically 1-10 liters for occupational sampling)StabilitySerum: refrigerate at 2-8°C for up to 7 days; freeze at -20°C or below for longer storage; protect from light as 1,4-Dioxane may be volatileHemolysis max500Lipemia max1000Icterus max500TAT72–168 hoursOrderroutine
## What is this test?


The 1,4-Dioxane test measures the amount of 1,4-dioxane in your blood serum. 1,4-Dioxane is a colorless liquid chemical compound primarily used as a solvent in industrial processes, including the production of chemicals, plastics, and some consumer products. This test helps determine if you have been exposed to 1,4-dioxane and at what level. It is commonly performed for occupational health monitoring, especially in workers who handle or are exposed to this chemical in manufacturing or industrial settings.


Reference range


No established reference range for serum; occupational exposure limit (OEL) for air: 1,4-Dioxane ≤ 1 ppm (3.6 mg/m³) as 8-hour TWA; biological exposure index (BEI) not establishedN/A

Specimen: serum

No specific preparation required; avoid exposure to 1,4-Dioxane-containing products (certain cosmetics, detergents, adhesives) for 24 hours prior to collection if possible; inform laboratory of occupational exposure history


## Clinical interpretation


How abnormal results are interpreted and what conditions they suggest.


### ◆Associated findings1

## Frequently asked questions
Why would I need this test?You may need this test if you work in an industry where 1,4-dioxane is used or produced, such as chemical manufacturing, plastics production, or certain laboratory settings. It is often part of routine occupational health monitoring to ensure your exposure levels remain within safe limits.Is the test safe?Yes, this is a standard blood test with minimal risks. You may experience slight bruising or tenderness at the needle site. The amount of blood drawn is small and well within safe limits.How should I prepare for this test?No special preparation is typically required. You should follow your doctor's instructions regarding any medications you are taking. Inform your healthcare provider about any chemicals you may have been exposed to recently.What do the results mean?Your test results will show the concentration of 1,4-dioxane in your blood. Your doctor will interpret these results based on occupational exposure guidelines and your specific work environment. Elevated levels may require protective measures or changes in workplace procedures.
## Sources
3
1. 1ATSDR - 1,4-DioxaneSource
2. 2OSHA - 1,4-DioxaneSource
3. 3NIOSH - 1,4-DioxaneSource


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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

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Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy